SAVE $10: As of September 15, the Apple Watch Series 9 (41mm, GPS) is on

Hong Kong is betting free alcohol and longer shopping hours will revive the city’s once-bustling nightlife. The government

Take out your sunnies, folks, and prepare to be blinded by Coach’s new electrifying metallic and patent leather bags. The beloved pillowy Coach Tabby Bag has undergone a sleek, edgy transformation and is ready to party. While the first edition of the Coach Tabby Bag came in whimsical, pastel-candy hues, the second highlights the bag in mirror metallics and pigmented patent leather. Just think of the new silhouettes as the original’s fashion-forward twin sister.

Aspartame, the artificial sweetener found in everything from diet drinks, yogurt, ice cream and breakfast cereals to medicines,

Anheuser-Busch InBev will sponsor the women’s 2023 World Cup in a nod to one of football’s fastest-growing areas,

It’s been six days since residents of a Tennessee city were told that diesel fuel spilled into a local reservoir, and most of them still can’t drink their tap water

The Formula 1 paddock heads to Montreal next for the Canadian Grand Prix. Max Verstappen won his third race in a row with a cruise of a victory in Spain last time out, with his lead in the F1 world championship now 53 points from Red Bull team-mate Sergio Perez. COMMENT: Ferrari’s F1 flaws all the more baffling after shock success at Le Mans It was an improved weekend in Barcelona for Mercedes though, with their revamped car showing improvements as Lewis Hamilton and George Russell came home second and third respectively. There was disappointment for Fernando Alonso though, who only finished seventh, while Ferrari’s Charles Leclerc finished outside the points in 11th. Verstappen won last year’s race in Montreal, seeing off Carlos Sainz in second, while F1 have dismissed speculation that this year’s race could be called off due to the wildfires causing air pollution in nearby regions. Follow live coverage from the Canadian Grand Prix with The Independent - FP1 starts at 6:30pm (BST). Read More F1 commentator sacked from BBC role after ‘inappropriate touching’ Lewis Hamilton plays down talk of imminent new Mercedes deal Ferrari’s F1 flaws all the more baffling after shock success at Le Mans

China released a series of measures intended to ease movement across and within its borders, as the country’s

Australia reached fever pitch ahead of its national team’s first appearance in a Women’s World Cup semi-final match,

Unborn babies are in a perpetual nutritional tug-of-war with their mothers due to a “greedy” gene inherited from their fathers, a new study suggests. Scientists from the University of Cambridge have found that foetuses use the gene to “remote-control” their mother into feeding them extra food and control her metabolism. While the mother’s body wants the baby to survive, it needs to keep enough glucose and fats circulating in her system for her own health in order to be able to deliver the child, breastfeed, and reproduce again. Amanda Sferruzzi-Perri, professor in Foetal and Placental Physiology, a Fellow of St John’s College and co-senior author of the paper, said: “It’s the first direct evidence that a gene inherited from the father is signalling to the mother to divert nutrients to the foetus.” Dr Miguel Constancia, MRC investigator based at the Wellcome-MRC Institute of Metabolic Science and co-senior author of the paper, said: “The baby’s remote control system is operated by genes that can be switched on or off depending on whether they are a ‘dad’s’ or ‘mum’s’ gene’, the so-called imprinted genes. “Genes controlled by the father are ‘greedy’ and ‘selfish’ and will tend to manipulate maternal resources for the benefit of the foetuses, so to grow them big and fittest. “Although pregnancy is largely cooperative, there is a big arena for potential conflict between the mother and the baby, with imprinted genes and the placenta thought to play key roles.” The new study looked at how the placenta communicates with the mother through the release of hormones so she can accommodate her baby’s growth. In pregnant mice, scientists selectively altered the signalling cells in the placenta that tell mothers to allocate nutrients to her developing foetuses. The baby’s genes controlled by the father tend to promote foetal growth and those controlled by the mother tend to limit foetal growth, experts say. Professor Sferruzzi-Perri explained: “Those genes from the mother that limit foetal growth are thought to be a mother’s way of ensuring her survival, so she doesn’t have a baby that takes all the nutrients and is too big and challenging to birth. “The mother also has a chance of having subsequent pregnancies potentially with different males in the future to pass on her genes more widely.” In the study researchers deleted the expression of an important gene called Igf2, which provides instructions for making a protein called “Insulin Like Growth Factor Two”. Similar to the hormone insulin, which is responsible for making glucose and controlling its levels in our circulation, the gene promotes foetal growth and plays a key part in the development of tissues including the placenta, liver, and brain. Dr Jorge Lopez-Tello, a lead author of the study based at Cambridge’s department of physiology, development and neuroscience, said: “If the function of Igf2 from the father is switched off in signalling cells, the mother doesn’t make enough amounts of glucose and lipids – fats – available in her circulation. “These nutrients, therefore, reach the foetus in insufficient amounts and the foetus doesn’t grow properly.” The scientists found that deleting the gene also affects production of other hormones that modulate the way the mother’s pancreas produces insulin, and how her liver and other metabolic organs respond. Babies with Igf2 gene defects can be overgrown or growth-stunted. And the researchers say that until now, it was not known that part of the gene’s role is to regulate signalling to the mother to allocate nutrients to the unborn child. The mice studied were smaller at birth and their offspring showed early signs of diabetes and obesity in later life. Professor Sferruzzi-Perri said: “Our research highlights how important the controlled allocation of nutrients to the foetus is for the lifelong health of the offspring, and the direct role the placenta plays. “The placenta is an amazing organ. At the end of pregnancy, the placenta is delivered by the mother, but the memories of how the placenta was functioning leaves a lasting legacy on the way those foetal organs have developed and then how they’re going to function through life.” The findings are published in the Cell Metabolism journal. Reporting by PA Read More It took until my thirties to realise I might not be white Carrie Johnson announces birth of third child with Boris Johnson: ‘Guess which name my husband chose’ How many children does Boris Johnson have? The meaning behind the name of Carrie and Boris Johnson’s third child Emilia Clarke’s brain haemorrhage ‘profoundly changed our lives’, says star’s mother How many children does Boris Johnson have?

It took only two years from its announcement for the AirPods to become the most

When China was in the midst of a pandemic-induced economic slump in 2020, then Premier Li Keqiang touted the idea of creating jobs by encouraging street vendors to set up shop across the country. That pitch was quickly shot down by close associates of leader Xi Jinping, who characterized the traditional trade as "unhygienic and uncivilized."