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Women more severely affected by ME, study claims
Women with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) tend to have more symptoms and co-occurring conditions than men, according to the world’s largest study of the disease. The study, entitled DecodeME, reveals women who have the condition for more than 10 years are more likely to experience increasingly severe symptoms as they get older. ME/CFS is estimated to affect more than 250,000 people in the UK, of all ages and from all social and economic backgrounds. Its key feature, called post-exertional malaise, is a delayed dramatic worsening of symptoms following minor physical effort. Other symptoms include pain, brain fog and extreme energy limitation that does not improve with rest. Causes are unknown and there is currently no diagnostic test or cure. Experts from the University of Edinburgh analysed anonymous survey questionnaires from more than 17,000 people with ME/CFS. Two-thirds of women, and slightly more than half of men, reported at least one active co-occurring condition. Similarly, 39.2% of women and 28.6% of men reported at least one inactive co-occurring condition. We discovered that the disease is worse for women, in older people, and many years after their ME/CFS started Professor Chris Ponting of the University of Edinburgh A condition was considered active if the participant had experienced symptoms in the preceding six months. The most common active co-occurring condition was irritable bowel syndrome, with clinical depression, fibromyalgia, anaemia and hypothyroidism also featuring prominently. Women also reported, on average, more symptoms than men – 42 compared with 36. The most common of these symptoms were brain fog – a term commonly used to describe the cognitive impairment experienced by participants – unrefreshing sleep and muscle pain. These findings highlight the very serious impact ME/CFS has on women who are disproportionately affected Sonya Chowdhury, chief executive of Action for M.E Participants were also asked to define the severity of their illness from mild to very severe using definitions from the UK’s National Institute for Health and Care Excellence guidelines. Experts identified that being a woman and having ME/CFS for more than 10 years are risk factors for severe illness, with symptoms increasing in intensity as they age. Professor Chris Ponting, study lead from the MRC human genetics unit at the University of Edinburgh’s Institute of Genetics and Cancer, said: “ME/CFS is a devastating disease affecting a UK population the size of Derby. “We discovered that the disease is worse for women, in older people, and many years after their ME/CFS started. “Our hope is that DecodeME’s genetic results will shed light on why certain groups are more susceptible to ME/CFS than others.” Sonya Chowdhury, chief executive of Action for M.E. and chair of the management group of the study, said: “These findings highlight the very serious impact ME/CFS has on women who are disproportionately affected. “It’s important to also recognise the impact that it has on men who have ME/CFS and we thank the 20,000 men and women who have already signed up to take part in this very important study. “We still need more to join us, so if you are 16 or older, live in the UK and have a diagnosis of ME/CFS, please do take part now to help us decode ME at www.decodeme.org.uk/portal.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live 4 hacks to get teens off the sofa and get active – as study warns of heart damage Taking adult education classes may lower risk of dementia, study suggests Indiyah Polack: I didn’t want to go on Love Island because of my acne
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Three quick and easy plant-based fakeaways to create at home
In the UK, we all love a good takeaway, but thanks to the cost-of-living crisis, many now see this as a luxury and are swapping going out with staying in and saving their pennies. To help recreate your top takeaway dishes, the pioneers at meat alternative brand Planted have pulled together three delicious fakeaway favourites that you can make with ease at home. From aromatic butter chicken to sumptuous satay kebabs and tender BBQ burgers, there’s something for everyone. Butter chicken Serves: 4 Ingredients: 2 tsp vegetable oil 1 onion, chopped 1 tsp garlic, chopped 1 tsp ginger, chopped 1½ tsp garam masala 1½ tsp ground cumin 1 tsp ground coriander 1 tomato, chopped 1 tsp chili powder 1 tsp salt 250ml coconut milk 1 tsp sugar For the marinade: 350g planted.chicken original ½ cup unflavoured yoghurt or vegetable yoghurt (optional) 1 tbsp minced garlic 1 tbsp finely chopped ginger 1½ tsp garam masala 1 tsp ground cumin 1 tsp turmeric 1 tsp chili powder 1 tsp salt Method: Mix the ingredients for the marinade well with the planted.chicken and marinate for at least 1 hour. Heat vegetable oil in a large pot and sauté onions until soft, then add garlic and ginger and sauté for 1 more minute. Add the garam masala, cumin and coriander and cook for 20 seconds, stirring regularly. Add the tomatoes, chili and salt and simmer for 15 minutes until the sauce thickens Put the sauce in a blender and mix until it has a creamy consistency, then put it back into the pot. Add the coconut milk and sugar to the sauce and bring to the boil. Allow liquid to cool, remove blender cap and firmly press a towel over the top. Fry the marinated planted.chicken in a pan until golden brown (approx 5 minutes), then add to the sauce and mix well. Serve with cooked rice. BBQ burger Ingredients: 4 pretzel buns 320g planted.pulled BBQ 1 tbsp rapeseed oil 150g sauerkraut 8 pickled cucumbers 4 onions 1 tbsp brown sugar 1 tsp tomato paste Salt and pepper 2 tbsp vegan butter 4 lettuce leaves 60g sweet mustard 60g BBQ sauce 1 tsp apple cider vinegar 1 tsp maple syrup Method: Cut the pretzel buns in half and toast the insides. Cut the pickled cucumbers into slices. Peel the onions and cut into rings. Then melt the vegan butter in a pan over medium heat, briefly fry the tomato paste in it and then add the onions and sugar and leave to brown for 15 minutes, stirring occasionally. Add salt and pepper if necessary. Mix the sweet mustard, BBQ sauce, apple cider vinegar and maple syrup to a sauce. Season to taste with salt and pepper. Heat the rapeseed oil in a pan and fry the planted.pulled BBQ in it for 3 minutes. Spread the sauce on the inside of the buns, top the burgers with sauerkraut, planted.pulled BBQ, lettuce leaves, pickles and the caramelised onions. Satay kebab Ingredients: 600g planted.chicken original 4 tbsp soy sauce 2 tbsp peanut butter 2 tbsp red curry paste 2 tbsp brown sugar/maple syrup 2 tsp garlic powder Salt and pepper Sesame oil for frying Skewers (wood or metal) For the peanut sauce: 1 small onion, chopped 2 cloves garlic, minced or crushed in garlic press 2 tsp sesame oil 2 tsp red curry paste 2 tbsp light soy sauce 2 tsp tamarind paste 2 tbsp brown sugar 240ml coconut milk 160g peanut butter Juice of one lime Method: For the marinade, mix all ingredients in a small bowl to form a paste. Put the planted.chicken on skewers and brush with marinade. Tip: arrange lengthwise so that a larger surface can be fried. For the peanut sauce, mince the onion while heating the sesame oil in a pot. Fry the chopped onions in the pot at medium heat until they are translucent. Add garlic and curry paste to the onions, mix and fry briefly. Reduce heat and then add the soy sauce, tamarind paste, sugar and coconut milk and mix well. Add the peanut butter, stir until smooth and mix in the juice of one lime. Keep the peanut sauce warm on low heat while the skewers are frying. Heat the sesame oil in a frying pan and fry the skewers over medium-high heat until golden brown. Serve planted.chicken skewers with the peanut sauce. Read More The Union Rye, review: Finally, a decent restaurant in this charming East Sussex town Missing Glastonbury? Here’s how to have a festival feast at home Four berry sweet recipes that go beyond strawberries and cream Can you whip up the perfect burger in just five minutes? These are the viral TikTok recipes you have to make this Father’s Day Eddie Huang: ‘I’ll never eat at BAO London – I know mine’s better’
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Afghan girls' education activist released from detention
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As the 'Hollywood of the South,' Atlanta has boomed. Its actors and crew are now at a crossroads
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This Home Manicure System Promises Long, Damage-Free Wear — But Does It Work?
I know gel manicures are probably not the greatest thing for my nails, but between the instant dry time, chip-free wear, and super-glossy finish? I can’t resist — I’m only human! However, as I’ve recently been taking a break from gel, I’ve been pampering my natural nails and trying to get them to a longer, stronger place. Unsurprisingly, my iPhone algorithm caught on and began to serve me endless home alternatives to salon gel. Most of them looked sketchy to say the least, but one of them managed to stop my thumb from scrolling: Manicurist Paris’ Green Flash system. It boasts instant dry time with its LED lamp, in addition to long, chip-resistant wear — all with an easy removal process that doesn’t damage natural nails. It sounded too good to be true, so naturally, I had to see for myself how it worked.
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The best headphones for every situation
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Dyson Week ends today: Save up to $200 on vacuums, hair care, and more
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