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Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

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With the cost of beer going up and up in the UK, holidaymakers are enjoying a pint for around a pound on holiday in Europe and the taste isn’t bad either. The British Beer & Pub Association recently found that on average a pint will set you back £4.07 in the UK - and £4.84 in London - which the Office of National Statistics has found is a yearly rise of nearly 12 per cent. However, finder.com puts the cost of the average pint in London at £5.50 and anyone who has been to the theatre recently will know the cost can be higher still. Perhaps surprisingly to some, the UK does not have the highest average price for a pint in Europe - with research by The Drinks Business last year giving that unwanted honour to Norway, where a pint will set you back £7.55. But while the cost of going to Europe will probably set you back more than you could save on the drinks - unless you are planning a long stay or a lot of beers - a cheaper price can ease the financial burden of going on holiday. Here are the places to go to in Europe for a cheap drink Although we one day hope they will again welcome tourists, Belarus and Ukraine are perhaps not the best holiday options in 2023 despite their cheap drink options. Vouchers.co.uk looked into Numbeo’s Cost of Living database to find the top ten cheapest pints in Europe in August last year and put the two countries at first and second respectively. Research found a pint will cost an average of 71p in Belarus and 90p in Ukraine. However, a better option might be Azerbaijan, another Eastern European nation where you can buy a pint for less than £1 with the average beer being just 91p. Moldova and Albania were not far behind at £1.05 and £1.07 respectively. Andrea Knowles, personal finance expert from Vouchers.co.uk said: “The price of everything seems to keep going up and up, and this includes your favourite tipple – and this seems to be the case whether you are visiting your local pub or looking for a refreshment whilst on holiday. “Whilst not all of these locations will be top of the list for holidaymakers this year, our analysis does well to show overall where holidaymakers can get the most bang for their buck when it comes to beer prices around the continent”. @simplyyykatie The cheapest European cities..?✈️ Who doesn't love a £1 pint?? #traveltiktok #europe #europetravel #cheaptravel ♬ Good Vibes (Instrumental) - Ellen Once Again Hungary, Poland, Romania and Bulgaria are good options too For more conventional holiday hotspots around Europe there is good beer to be had for a great price in Hungary, Poland, Romania and Bulgaria - all countries that are on the end of plenty of flights from the UK on a daily basis. TikTok influencer Simply Katie has travelled Europe in search of the cheapest beer and found Hungarian capital Budapest can offer a pint for £1.21. The city is set to host the World Athletics Championships next month but is actually the most expensive in the country for the price of beer, according to vouchers.co.uk. The website found a drink will cost only £0.87 in Szeged if you are prepared to travel further into Hungary. “There are so many sights to see and you have to visit the thermal baths,” Katie said in the video. Simply Katie found Romanian capital Bucharest was a good option - with a pint going for just £1.48. She also found over in Poland that £2 is all it takes for a good beer in Krakow, while further digging can find that a beer can be bought for £1.49 in the historic city of Lublin. Another TikTok user Staceyistired commented: “No joke I went to Krakow two years ago and spent £60 in 3 days, we did all the museums.” "Who doesn’t love a £1 pint?" Simply Katie wrote with the accompanying video last month. Previous Euro travellers have also found Sofia in Bulgaria to be a good option with a Kozel beer on tap for the equivalent of around £2. Here is the full top ten according to the vouchers.co.uk list 1. Belarus (£0.71) 2. Ukraine (£0.90) 3. Azerbaijan (£0.91) 4. Moldova (£1.05) 5. Albania (£1.07) 6. North Macedonia (£1.24) 7. Kosovo [Disputed Territory] (£1.28) 8. Bosnia And Herzegovina (£1.29) 9. Bulgaria (£1.31) 10. Hungary (£1.31) Read More Heineken says customers bought less beer after price increases Cats on tap: Meet the New York brewery cats living their best lives Harry Potter superfans celebrate birthday of wizard with movies and ‘butterbeer’ LGBTQ+ community proud and visible at Women's World Cup Youth coach hopes Women's World Cup raises soccer's profile for Maori people in New Zealand New Zealand Women's World Cup team evacuated because of hotel fire in second security incident

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PARK RIDGE, N.J.--(BUSINESS WIRE)--Sep 5, 2023--

Waterloo Road star Adam Thomas has announced he has rheumatoid arthritis ahead of his Strictly Come Dancing debut next month. In an Instagram post shared on 11 August, the actor, 35, told his followers that he initially thought that the condition was something people were diagnosed with “later on in life”. “As much as I act like a kid, my body is telling another story…” he wrote. “I thought that was something people, later on in their life get… but that’s not the case, clearly!” “I’ve been in a lot of pain since January,” he continued. “It started with my knees and then travelled to my wrists, fingers and now ankles and toes.” Thomas explained: “I never knew what was happening and finally after several blood tests and back and forth to doctors and hospitals, I’ve been diagnosed with rheumatoid arthritis!” The actor, who is competing in this year’s instalment of Strictly Come Dancing but has said that he is “up for the challenge”. “It really couldn’t have come at a better time I’m a firm believer of everything happening for a reason, and I know the journey I’ve been on was meant to happen, to never take small things in life for granted!” he assured fans. “…Like going for a run, playing with my kids and just being able to walk with no pain!” “I know it’s going to be tough and I’ve definitely got my work cut out but am up for the challenge and can not wait to get on that dance floor!!” What is rheumatoid arthritis? Rheumatoid arthritis is an autoimmune disease and long-term condition that typically affects the hands, feet and wrists. Benjamin Ellis, a Consultant Rheumatologist and Senior Clinical Policy Advisor to Versus Arthritis (the UK’s largest arthritis charity), told The Independent: “Rheumatoid arthritis affects people of all ages, and happens when the immune system – the body’s natural defence system – goes out of balance and attacks the joints making them inflamed, swollen and painful.” Some people with rheumatoid arthritis also experience problems in other parts of the body, or more general symptoms such as tiredness and weight loss. According to the NHS, the condition often starts when a person is between 30 and 50, and women are more likely to be affected than men. What causes rheumatoid arthritis? The NHS states that it is not clear what triggers this problem with the immune system, but women, people who smoke, and people who have a family history of rheumatoid arthritis are at increased risk. Depending on how much pain a person experiences, their daily tasks can become difficult and take longer to do. Is there a cure for rheumatoid arthritis? There is no cure for rheumatoid arthritis but an early diagnosis and treatment allows people with the condition to have long periods between flare-ups. The NHS states that the main treatment options include taking medicine to relieve symptoms, supportive treatments like physiotherapy and surgery to correct any joint problems. Ellis told The Independent that early treatment can reduce the risk of long-term joint damage. “Urgent and intensive treatments to rebalance the immune system improve symptoms and reduce the risk of long-term, disabling joint damage caused by this inflammation, but NHS delays mean that not everyone is getting the treatment they need, as quickly as they need it,” said Ellis. “Keeping moving is great for the joints, whatever type of arthritis you have. The best thing is to pick something you enjoy, and listen to your body to do the right amount that works for you, whether that’s walking, yoga, swimming or dancing.” What are the complications of rheumatoid arthritis? Having rheumatoid arthritis can sometimes lead to other conditions like carpal tunnel syndrome or inflammation of other areas of the body, causing additional symptoms. The NHS states that some complications can be more serious, like an increased risk of heart attack and stroke. But it advises that managing the condition early on can help to reduce the risk of complications. You can find out more about living with Rheumatoid arthritis on the NHS website here. For further support and information about arthritis, visit www.versusarthritis.org or call the free Versus Arthritis helpline on 0800 5200 520 . Read More Adam Thomas diagnosed with long-term health condition ahead of Strictly Come Dancing Husband ‘ruins’ dinner because of his wife’s typo: ‘The worst kind of control freak’ Fan who went into labour at Pink concert names newborn son after her Adam Thomas diagnosed with long-term health condition ahead of Strictly Come Dancing From Angela Scanlon to Zara McDermott: The fashion of this year’s Strictly contestants Linda Evangelista opens up about co-parenting with son’s stepmother Salma Hayek