A small but growing group of young teens are turning to drastic treatments to lose large amounts of weight, things like body-altering surgery and new drugs that rewire metabolism

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Using existing drugs to treat cervical cancer before standard treatment could lead to a 35% reduction in the risk of relapse or death, a new study suggests. Researchers from the UCL Cancer Institute and UCLH looked into whether a short course of induction chemotherapy (IC), where a drug is used to destroy as many cancer cells as possible, before chemoradiation (CRT), could help with this. Here’s everything you need to know about the findings… What is cervical cancer? According to the NHS website, cervical cancer is a type of cancer found anywhere near the cervix – the opening between the vagina and the womb (uterus), which is also known as the neck of the womb. Most cervical cancers grow very slowly and are caused by an infection from specific types of human papillomavirus (HPV) and mostly affect women under the age of 45. According to Jo’s Cervical Cancer Trust, symptoms include vaginal bleeding that is unusual to you, changes to vaginal discharge, discomfort during sex and pain in your lower back or pelvis. Changes to cells can be spotted by a cervical screening, and then treated before they turn into cancer. There are around 3,200 new cases every year in the UK, with the five-year survival rate being around 70%, according to Cancer Research UK. CRT has been the standard treatment for cervical cancer patients since 1999, but even though there have been overall significant developments in radiation therapy techniques, up to 30% of people experience their cancer coming back. What did the research involve? Over a 10-year period, 500 patients who had been diagnosed with cervical cancer – that was large enough to see without a microscope but hadn’t spread to other parts of the body – took part in the Interlace trial at hospitals in the UK, Mexico, India, Italy and Brazil. Researchers looked into whether a short course of IC before CRT could reduce rates of relapse and death. What results were found? After five years, researchers discovered that 80% of the people who received a combination of chemotherapy and radiotherapy were alive, whilst 73% had not seen their cancer return or spread. A major benefit, according to researchers, is that it can be incorporated into standard of care treatment relatively quickly, because cheap, accessible and already-approved ingredients such as carboplatin and paclitaxel are needed for IC. “Our trial shows that this short course of additional chemotherapy delivered immediately before the standard CRT can reduce the risk of the cancer returning or death by 35%,” said Dr Mary McCormack, lead investigator of the trial from UCL Cancer Institute and UCLH. “This is the biggest improvement in outcome in this disease in over 20 years. “I’m incredibly proud of all the patients who participated in the trial; their contribution has allowed us to gather the evidence needed to improve treatment of cervical cancer patients everywhere. “We couldn’t have done this without the generous support of Cancer Research UK.” Why is the research important? Dr Iain Foulkes, executive director of research and innovation at Cancer Research UK, said: “Timing is everything when you’re treating cancer. The simple act of adding induction chemotherapy to the start of chemoradiation treatment for cervical cancer has delivered remarkable results in this trial. “A growing body of evidence is showing the value of additional rounds of chemotherapy before other treatments like surgery and radiotherapy in several other cancers. “Not only can it reduce the chances of cancer coming back, it can be delivered quickly using drugs already available worldwide. “We’re excited for the improvements this trial could bring to cervical cancer treatment and hope short courses of induction chemotherapy will be rapidly adopted in the clinic.”

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Lewis Hamilton said his “disappointing” result in qualifying for the British Grand Prix must serve as a “wake-up call” for Mercedes. Hamilton will start his home race in front of a 150,000 sell-out crowd at Silverstone only in seventh place, with team-mate George Russell one spot better off on the grid. As Max Verstappen, perhaps predictably, raced to his fifth consecutive pole position, McLaren stung a surprise with Lando Norris and team-mate Oscar Piastri second and third respectively in their upgraded machines. Informed of his position over the radio, Hamilton said: “We are so slow.” McLaren’s resurgence means Hamilton is now even further away from the front – qualifying half-a-second off Verstappen – despite Mercedes bringing a new front wing to Silverstone. “It is not a blow, but it is just a wake-up call for us,” said Hamilton. “Others are overtaking us and we need to do more. “I will be optimistic and do my best to get on the podium, but realistically I am not sure we can. We have two Ferraris and two McLarens ahead of us so it is going to be a tough race. “It is always a great feeling to be at the British Grand Prix, but today it was disappointing that we could not deliver for the fans. Hopefully we can tomorrow.” Hamilton is the most successful driver at the British Grand Prix – winning seven of the last 10 races staged here. But 580 days have now passed since Hamilton last took to the top step of the podium – a run of 32 races which extends back to the final round of the 2021 season. Mercedes’ major upgrade arrived at Monaco in May, and Hamilton delivered successive podiums at the ensuing rounds in Spain and Canada to provide him with hope he might soon be back in winning contention. But he finished only eighth in Austria a week ago, and he is facing a tall order to salvage a respectable result on Sunday. McLaren have been well off the pace so far this year, but their new package – which Hamilton likened to Verstappen’s dominant Red Bull machine – has propelled them ahead of the Silver Arrows. “I am not surprised by McLaren because if you look at the car it makes sense,” said Hamilton. “If you put it alongside a Red Bull, it looks very similar down the sides and it is working. They had the edge on us at the last race so I anticipate tomorrow will be the same. “McLaren have been on a bad run for so long so I am happy for them. We have another team up in the mix which is what we want to see in the sport.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Max Verstappen pips Lando Norris to pole position at British Grand Prix Lewis Hamilton 15th in practice for British GP as Max Verstappen dominates again Lewis Hamilton promises to keep his cool on team radio after Austrian flashpoint

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Lewis Hamilton fears there is a “high chance” that Max Verstappen will win all 10 remaining races this season – and believes the Dutchman’s crushing dominance could last until 2026. Following a four-week summer shutdown, Formula One fires up this weekend at Verstappen’s home round in the Netherlands. Verstappen has won the last eight races and he will match Sebastian Vettel’s record of nine on the spin for Red Bull in 2013 if he triumphs in front of his orange-clad Dutch fans here on Sunday. Such is the dominance of Verstappen’s machine – and the two-time world champion’s supreme form – there is a feeling in the paddock, not only that Red Bull could become the first team to go through a campaign unbeaten, but that Verstappen could be victorious at each of the concluding 10 rounds. “There is a high chance that he (Verstappen) will win every race,” said Hamilton, 38. “He hasn’t made any mistakes and the team hasn’t made many this year. They might win everything. “But later on in the year, maybe we will get closer and we are hopeful we can challenge them at some point – whether that is this weekend, or who knows where? If there are any mistakes or mishaps, we will be right there to capitalise.” Verstappen has dominated since F1’s regulations were overhauled at the start of last season, with his comfortable victory at the concluding round before the break in Belgium his 10th from 12 so far and his 19th from his last 23 outings. He is a staggering 125 points clear in the standings as he closes in on a hat-trick of titles. Ferrari’s Charles Leclerc predicted on Thursday that it would be “very, very difficult” to catch Verstappen and Red Bull before the sport’s next major rule change in 2026. And Hamilton continued: “The fact is Red Bull are ahead and they have most likely started development on next year’s car a month before anybody else. It is very, very possible that Charles could be right. “We are working on the steep gradient to develop our car and close the gap. Whether or not we can, next year will be the proof.” I am hoping we are closer or in shooting range of a podium this weekend Lewis Hamilton Hamilton’s £40million-a-year contract expires at the end of the season and the Briton said on Thursday that were there was no update on his next deal, despite team principal Toto Wolff claiming – ahead of the Canadian Grand Prix on June 18 – that his star driver’s future would be resolved in “days rather than weeks”. Hamilton is fourth in the standings, 41 points adrift of Verstappen’s Red Bull team-mate Sergio Perez who occupies the runner-up spot, while Mercedes are second in the team standings, an eye-watering 256 points behind Red Bull, but 51 points clear of Ferrari. “It is a huge achievement to be second in the championship and it is something I feel has been overlooked,” said Hamilton. “We want to win but I am really proud of the team and the steps we have taken. “The guys think this track is not too different to Budapest and our car was good in Budapest. Even last year when the car was not great in Zandvoort, we were closer to the front. “George (Russell) finished second and at one point I was hunting down the lead so I am hoping we are closer or in shooting range of a podium this weekend. “We have the belief we will get there. And my goal is to try and keep that second place in the constructors’ championship and hunt down second in the drivers’ standings.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Haas announce Kevin Magnussen and Nico Hulkenberg staying for 2024 Lewis Hamilton gives blunt response to Felipe Massa’s legal action over 2008 title Charles Leclerc gives gloomy prediction on how quick Ferrari will catch Red Bull

The chairman of Richemont, the Swiss owner of Cartier and watchmakers including IWC and Vacheron Constantin, said inflation