An orange-tinged smog caused by Canada's wildfires shrouded New York on Wednesday, obscuring its famous skyscrapers and causing residents to don face masks, as cities along the US...

Updated COVID-19 shots are coming soon, part of a trio of fall vaccines that doctors hope will help avoid another “tripledemic."

Using existing drugs to treat cervical cancer before standard treatment could lead to a 35% reduction in the risk of relapse or death, a new study suggests. Researchers from the UCL Cancer Institute and UCLH looked into whether a short course of induction chemotherapy (IC), where a drug is used to destroy as many cancer cells as possible, before chemoradiation (CRT), could help with this. Here’s everything you need to know about the findings… What is cervical cancer? According to the NHS website, cervical cancer is a type of cancer found anywhere near the cervix – the opening between the vagina and the womb (uterus), which is also known as the neck of the womb. Most cervical cancers grow very slowly and are caused by an infection from specific types of human papillomavirus (HPV) and mostly affect women under the age of 45. According to Jo’s Cervical Cancer Trust, symptoms include vaginal bleeding that is unusual to you, changes to vaginal discharge, discomfort during sex and pain in your lower back or pelvis. Changes to cells can be spotted by a cervical screening, and then treated before they turn into cancer. There are around 3,200 new cases every year in the UK, with the five-year survival rate being around 70%, according to Cancer Research UK. CRT has been the standard treatment for cervical cancer patients since 1999, but even though there have been overall significant developments in radiation therapy techniques, up to 30% of people experience their cancer coming back. What did the research involve? Over a 10-year period, 500 patients who had been diagnosed with cervical cancer – that was large enough to see without a microscope but hadn’t spread to other parts of the body – took part in the Interlace trial at hospitals in the UK, Mexico, India, Italy and Brazil. Researchers looked into whether a short course of IC before CRT could reduce rates of relapse and death. What results were found? After five years, researchers discovered that 80% of the people who received a combination of chemotherapy and radiotherapy were alive, whilst 73% had not seen their cancer return or spread. A major benefit, according to researchers, is that it can be incorporated into standard of care treatment relatively quickly, because cheap, accessible and already-approved ingredients such as carboplatin and paclitaxel are needed for IC. “Our trial shows that this short course of additional chemotherapy delivered immediately before the standard CRT can reduce the risk of the cancer returning or death by 35%,” said Dr Mary McCormack, lead investigator of the trial from UCL Cancer Institute and UCLH. “This is the biggest improvement in outcome in this disease in over 20 years. “I’m incredibly proud of all the patients who participated in the trial; their contribution has allowed us to gather the evidence needed to improve treatment of cervical cancer patients everywhere. “We couldn’t have done this without the generous support of Cancer Research UK.” Why is the research important? Dr Iain Foulkes, executive director of research and innovation at Cancer Research UK, said: “Timing is everything when you’re treating cancer. The simple act of adding induction chemotherapy to the start of chemoradiation treatment for cervical cancer has delivered remarkable results in this trial. “A growing body of evidence is showing the value of additional rounds of chemotherapy before other treatments like surgery and radiotherapy in several other cancers. “Not only can it reduce the chances of cancer coming back, it can be delivered quickly using drugs already available worldwide. “We’re excited for the improvements this trial could bring to cervical cancer treatment and hope short courses of induction chemotherapy will be rapidly adopted in the clinic.”

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Tens of thousands of South Koreans brought rainbow pride to the streets of Seoul on Saturday for an annual celebration of LGBTQ rights, while demonstrators against them snagged a prime...

Attracting over 18 million tourists a year, Amsterdam has become the hot spot for travellers across the globe. Filled with tree-lined streets, picturesque canals and some of the finest culinary creations and art, the Dutch city has something for everyone – despite the stereotypes. Now, we can't speak about Dam without addressing the elephant in the room. You could be a foodie; an art enthusiast; a world traveller, or simply passing through the city on a connecting flight – but you'll inevitably be asked by friends, family and peers about your smoking habits – or lack of. Yes, it's legal – but it certainly isn't the be-all, end-all. In fact, tourists who have had the pleasure of visiting Amsterdam recently would have noticed the absence of smoke in the air, which is down to a newly enforced rule last month. There's much, much more to the beautiful, culturally enriched city. Sign up for our free Indy100 weekly newsletter Nestled in the Museum Quarter of the city resides Jan Luyken, a newly-renovated property surrounded by depths of culture and an elegant shopping street. Think, the Bond Street of Amsterdam. From rich-coloured walls graced with contemporary art to grande mirrors and fringed lampshades, it's no surprise l immediately fell for Jan Luyken. The moment you step into the hidden gem, you feel the essence of laidback luxury and incredible attention to detail woven throughout. There's not a corner in the hotel that ignores the memo, from the reception area adorned with delicate glassware and vibrant flower to the rooms that boast comfortable beds, stunning Amsterdam views and tons of natural light. Not to mention, Jan Luyken has a host of some of the friendliest staff members happy to assist with any questions or concerns. They were also equipped with recommendations on some of the area's best fine-dining restaurants and world-famous museums and There are also plenty of shared spaces dotted around the ground floor – perfect for winding down after a long day exploring the city. There's a library decked out with an array of books and lifestyle magazines and plenty of space to truly make Amsterdam feel like a home away from home – especially for a solo traveller like myself. Jan Luyken even provides guests with a kitchen, complete with top-of-the-range Smeg appliances and complimentary baked goods, beverages and fresh fruit. The garden terrace adds an extra special spin to Jan Luyken, as outdoor space is often considered quite a rarity among hotels. It's located next to an aesthetically pleasing gym that makes working out feel that little bit easier. With a hotel so impressive, it can sometimes be tempting to stay in and around it – but with 48 hours in the city, I had to temporarily leave my newfound home comforts to prove that Amsterdam is much more than the stereotypes. Museums Amsterdam does many things well, museums being one of them. The city is jam-packed with cultural experiences, from fine art to photography and history. Two days certainly won't get you through the array of galleries across the city, but there are two in particular that should not be missed. Moco Museum: Founded in 2016, the independent museum boasts a variety of modern, contemporary, and street art. Here, you will find pieces from Jean-Michel Basquiat, Banksy, Icy & Sot, JR, KAWS, Keith Haring, Jeff Koons, Damien Hirst, Tracey Emin, Yayoi Kusama, THE KID, Andy Warhol, Studio Irma, among many more. The Museum of Prostitution: While Amsterdam's sex industry remains open, there's still an air of mystery surrounding it. At the world's first prostitution museum, you will learn about the Red Lights Secrets through an interactive experience. Without giving too much away, the museum delves into the history of sex work in the city, what a typical room looks like and positive testimonials. It also does not shy away from the darker truths of the industry, such as trafficking and unsolved murder cases. Parks Vondelpark: Considered one of the city's most famous parks, this charming area makes the perfect destination to wind down from walking around the city after a long day. During the summer months, there's a host of activities, bandstands – and it even has its own Picasso sculpture hidden along the path. Food Dinner in the Pulitzer Garden: For the foodies, this al-fresco dining experience is a must. Inspired by modern-Dutch cuisine, it offers a wide range of impressive culinary creations and beautifully crafted cocktails. This gem is open for breakfast, lunch and dinner, with an idyllic view of the tranquil gardens. For more information about Jan Luyken, click here. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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