You may have thought mermaids were the stuff of cartoons and fairytales, but you'd be

Ryan Kelly's wife, Emma, was 19 weeks pregnant with their daughter, Mary Kate, when the child's heart stopped for 'reasons unknown'

We are in the eye of the Black Friday hurricane, valiantly snatching deals as they

ANCHORAGE, Alaska--(BUSINESS WIRE)--Jul 31, 2023--

Workers in the US are getting record-breaking wage hikes this year thanks to strategic strikes and stunning contract

Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

In the shadow of Auckland's Eden Park stadium, a neighborhood watering hole has become a home away from home for the hordes of American fans who have traveled thousands of miles to cheer on the US team at the Women's World Cup.

As he prepared the biggest fashion show of the year in Paris on Tuesday, musician-turned-designer Pharrell Williams told AFP he was conscious of the traumatic...

Kiyoshi Hashimoto's machinery factory outside Tokyo should be buzzing with industry. Instead, it's so quiet you can hear...

Ex-Navy SEAL Robert J O'Neill who 'killed Osama Bin Laden' allegedly assaulted a guard with racial slurs after a drunken night at a bar on August 23

A mother has questioned whether children should be “forced” to share after revealing an incident in which her son was allegedly “pushed” by another child on a splash pad for not sharing. Skye Amundsen, a mother from Maryland who goes by the username @hopeandplum on TikTok, reflected on the incident in a video posted earlier this month. According to Amundsen, who noted that the video was a “message to the mom that had the audacity to tell me that my son should have to share at the splash pad,” she and her two-year-old son had been playing at a local park with an outdoor sprinkler when the confrontation occurred. “Now, hear me out before you judge me. My son is two. He’s playing. He likes to step on the little things on the splash pad and stop them from splashing up,” the TikToker said. “This splash pad has tons of these, so he’s not hurting anyone.” In the video, the TikToker said that a little girl, who was “unhappy” with her son’s behaviour, then walked up to the two year old and “pushes him”. “She’s bigger than him and she pushes him. And my son’s like: ‘No’ and he steps back on it,” Amundsen recalled. “And she pushes him again.” According to Amundsen, she was “sitting there watching” and “waiting” for the mother of the other child to intervene. “I was like, well, you know, I’m going to give her a chance,” the TikToker said. @hopeandplum What do you think? We don’t force sharing and find our kids do it naturally most of the time. But why would anyone share with someone being mean? #newmomtips #summermom #momlife ♬ original sound - hope&plum | Baby Carriers Amundsen said that the other mother didn’t intervene despite the woman’s daughter allegedly pushing her two year old for a third time. However, after the third time, the TikToker said her son got “mad” and pushed the other child back. “So I intervene, because I’m his mother and I’m not going to let him push people,” Amundsen continued, adding that, as she was talking to her son, the other mother approached her to confront her about her son’s behaviour. “As I’m talking to my son, this woman has the audacity to say to me: ‘You should really teach your son to learn how to share, it would be better for him,’” the TikToker said. “I’m sorry, my son should learn how to share? Your daughter walked up and shoved my son three times, so my child should allow your child to push him and that’s acceptable and he should share with that human?” In the video, Amundsen then acknowledged that “everyone has different opinions on sharing,” and that she “likes” sharing and “thinks it’s nice,” but also doesn’t believe “you have to force your child to share, especially when another child is getting physical with them”. According to Amundsen, she ultimately told the other mother that they could “agree to disagree” when it came to their respective opinions about sharing. As of 25 July, the TikToker’s video, which she captioned: “What do you think? We don’t force sharing and find our kids do it naturally most of the time. But why would anyone share with someone being mean?” has been viewed more than 609,000 times, prompting other parents to weigh in in the comments. In response, the majority of viewers said they agreed with Amundsen on the basis that sharing shouldn’t be expected after “pushing”. “I totally agree with you. Definitely not sharing after pushing. Oh heck no,” one person wrote. Another said: “Absolutely agree. Also what is he supposed to share? I don’t understand, she wants him to let her use the single water spout that he was playing with?” “Wowww, the nerve of that other mom. In all fairness, you have better control than me,” someone else wrote, prompting Amundsen to reveal that she was “too stunned to speak” during the confrontation. In response to another comment, she said she was in “true shock” but that she was later “kicking” herself for “not saying more”. The Independent has contacted Amundsen for comment. Read More Woman claims restaurant ‘hack’ for toddlers solves family dinners out Woman praised for refusing to switch first class seat on plane with child Mom sparks backlash for piercing newborn’s ears in hospital: ‘How is that even legal?’ Schoolboy almost dies from swallowing magnets for TikTok challenge Woman shares honest review of New York City apartment TikTok mom slammed after making 5-year-old son run in 104 degree heat

The "Barbie" film's release was delayed in Pakistan's Punjab province Friday over "objectionable...