Planning on squirting some ketchup on your hot dog at a barbecue this weekend? You may be seeing red. Inflation has caught up to ketchup.

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Chrissy Teigen had a hilarious reaction to her latest wardrobe mishap. The model, 37, took to Instagram over the weekend to share a snap of her outfit at the 2023 Baby2Baby Gala. For the occasion, she opted for a black dress with a high-knee slit adorned with a sparkling 3D flower decal. She also paired the outfit with a gold clutch and black heels. As she shared photos of the event on her since-expired Instagram Story, captured by People, she revealed that she had a bit of a wardrobe problem during the event. In the picture, she was seen sitting in a chair with her back turned, as her dress accidentally slipped open along its zipper. Teigen, who was bent over in the photo, continued to poke fun at the dress malfunction in the caption, writing: “Oh lol.” This isn’t the first time that Teigen has shared a candid reaction to a wardrobe issue. Back in 2017, fans noticed her shirt happened to be sheer while she was sitting in the stands at the Super Bowl with her husband, John Legend. However, Teigen didn’t hesitate to play the situation off on social media. At the time, per Us Weekly, she simply retweeted the video and wrote: “Boom goes the dynamite.” On 11 November, the mother of four was one of the many famous faces at the annual gala that raises money for Baby2Baby, which “provides children living in poverty with diapers, clothing and all the basic necessities that every child deserves,” according to its official website. The star-studded guest list at the event included Kim Kardashian, Salma Hayek, Olivia Wilde, Heidi Klum, Matthew McConaughey, and Zoe Saldaña. This year, Channing Tatum also presented Hayek with the Giving Tree Award, in honour of the work that her charity has done to help underprivileged children in Mexico. “All children are our children. We have a responsibility. They hold in their hands our future. They are our hope,” she said during her speech, per The Hollywood Reporter. “Dignity is an essential; diapers are dignity, make no mistake. Love is an essential. For all these children and all the mothers and all their families, how can we say ‘Let’s love, not hate,’ but how do you teach compassion and empathy to people who have never felt compassion and empathy from anyone?” Hayek concluded: “So, in everything you donate and everything that Baby2Baby brings to every single home or street, there is an intention. It’s not just money. It is love. It is compassion. It is caring. We are all interconnected.” Read More The Wrong Coat? You’re bang on trend my friend ‘I made $2k in 24hrs’: These sellers built businesses off Beyonce’s tour – now what?

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Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Parisians woke up on Friday to a world without rented electric scooters, loathed as a pedestrian-bothering nuisance by some...