The US Federal Trade Commission sued Amazon.com Inc. Wednesday, alleging the e-commerce giant duped consumers into signing up

ChatGPT is down for subscribers and free users. According to OpenAI's status monitoring site and

Quick: What did you buy your dad for Father’s Day? If your answer is a flustered, “Wait, when is that?!” then you’re in the right place for last-minute, inexpensive, and unique Father’s Day gifts. With less than three weeks until the celebratory day, it’s time to start shopping for your favorite father figures, whether that be your dad, grandfather, uncles, godfather, brother, and/or friends.

When iOS 17 rolled out, Apple made a change that irked some iPhone owners: the

TL;DR: As of August 30, you can get the Portable Conversion Cable for Nintendo Switch

The Supreme Court has preserved the system that gives preference to Native American families in foster care and adoption proceedings of Native children

Melted ice cream, cockle popcorn and a no-egg-white omelet are among the most unusual hotel room service requests from travelers across the globe, according to a recent study.

(Reuters) -MGM Resorts said on Wednesday its hotels and casinos were back to normal operations but it was working to

UK Prime Minister Rishi Sunak blamed his Greek counterpart for their diplomatic spat and in comments that risk

Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

Herman Miller is often considered the be-all, end-all for expensive and exquisitely ergonomic office and

You might want to start leaving your door open at night, if new advice from sleep experts is anything to go by. New guidance might just change people’s choices when it comes to sleeping habits as we approach the warmer summer weather. While purchasing a fan is recommended for keeping cool when it comes to hotter temperatures, opening doors can do a lot when it comes to air circulation at night. “Surprisingly, only 60 per cent of adults sleep with their door closed meaning that 40 per cent sleep with their door open,” says Rex Isap, CEO and sleep expert at Happy Beds. Sign up to our free Indy100 weekly newsletter Explaining the implications of leaving doors open, Isep added [via Ideal Home]: “Firstly, a study found that those who slept with the bedroom door open reported a better and longer night’s sleep than those who slept with the door close. The reasoning behind this is that leaving the door open helped regulate the temperature in the room by making the temperature slightly lower, averaging 19 degrees Celsius.” Isap added: “Given that between 18 and 20 degrees Celsius is the ideal bedroom temperature, this naturally makes it easier for a person to fall asleep. It also makes it the ideal thing for a person to do if they suffer from night sweats, are going through menopause, or are generally overheating from the hot weather.” It’s not just a case of improving air flow and better maintaining temperatures either, as Sammy Margo at Dreams claims that leaving doors open also connects sleepers with the rest of their house and improves natural light in the mornings. Margo said: “Sleeping with an open door can also create a sense of openness and connection to the rest of your living space. It can alleviate feelings of isolation or confinement and promote a more positive and harmonious atmosphere in your home. It also opens the bedroom up to natural light from other areas of the house which can help in the morning!” Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.