Angelina Jolie has urged women with a history of cancer in their family to “look after” themselves and “take mamograms, blood tests and ultrasounds”. The actor posted a touching tribute to her late mum on Instagram for what would have been her 73rd birthday. Marcia Lynne ‘Marcheline’ Bertrand – also an actor – died of ovarian cancer in 2007, after also being diagnosed with breast cancer. Jolie underwent a prophylactic double mastectomy in 2013, because she carries a gene called BRCA1 that significantly increases the odds of developing breast or ovarian cancer. The 47-year-old posted: “[My mother] passed away 15 years ago after a long struggle with breast and ovarian cancer”. “In June, I will be a month away from the age when she was diagnosed. I have had preventive surgeries to try to lessen the chances but I continue to have check ups. “My mom loved Hendrix. And would always sign her letters Kiss the Sky. It took on new meaning after she passed. “Sending my love to those who have also lost loved ones and strength to those who are fighting at this very moment for their lives and the lives of those they love. “And to other women, please take the time to look after yourself and go for your mammograms and blood tests or ultrasounds, particularly if you have a family history of cancer.” What the experts say Ovarian cancer affects the two ovaries that store eggs. Its symptoms are often overlooked. According to Target Ovarian Cancer, the four main symptoms are persistent bloating; pelvic or abdominal pain; feeling full or a loss of appetite and an increased need to urinate. “The term bloating is often used to describe a feeling of fullness in the tummy, which can often be associated with the lower abdomen looking swollen,” said Dr Susanna Unsworth, women’s health expert and in-house gynaecology expert for Intimina. “Bloating is often a consequence of bowel issues, but it is also recognised as one of the potential symptoms of ovarian cancer. “Ovarian cancer has been described as a ‘silent killer’ as the symptoms can often be mild and may go unnoticed in the early stages of the disease,” she added. “By the time someone consults with a doctor, the cancer may have already become quite widespread. Research done in 2021 by CoppaFeel! found that one in seven women in the UK will be affected by breast cancer in their lifetime, and one in nine in Ireland. According to the NHS website, you should see your GP if you find a new lump, thickened skin, a change in the size or shape of your breasts, nipple fluid or discharge, lumps or swelling in your armpits, a change in skin texture or nipple appearance or a rash like eczema. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Georgia Toffolo on Jungle exit: ‘You can show your acne and be beautiful at the same time’ Eurovision: Liverpool’s trendsetting musical icons 14 clever ways to make small rooms look bigger

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Scientists in Israel have created a model of a human embryo from stem cells, without using sperm, eggs or a womb. A team at Israel's Weizmann Institute of Science made the model, which resembles an embryo at day 14, when it acquires internal structures but before it lays down the foundations for body organs, and the work was published in the journal Nature. But the scientists involved said it would take a long time yet to create an embryo from scratch. Team leader Jacob Hanna said the team took stem cells derived from adult human skin cells, as well as others cultured in the lab, then reverted the cells to an early state.They then manipulated them to make a model of an embryo, rather than an actual or synthetic one. "The question is, when does an embryo model become considered an embryo? When that happens, we know the regulations. At the moment we are really, really far off from that point," Hanna said. However, they said the work could open the door to new ways to test the effect of drugs on pregnancies, better understand miscarriages and genetic diseases, and maybe grow transplant tissues and organs. "They are not identical. There are differences from human embryos, but still, this is the first time, if you open an atlas or a textbook, you can say - yeah I can really see the similarity between them," said Hanna. "In about 1 percent of the aggregates we can see that the cells start differentiating correctly, migrating and sorting themselves into the correct structure, and the farthest we could get is day 14 in human embryo development," he said. Their next goal, Hanna said, is to advance to day 21 and also reach a threshold of a 50 per cent success rate. Magdalena Żernicka-Goetz, a professor of development and stem cells at the University of Cambridge, said the study joins six other similar human embryo-like models published from teams around the world this year, including from her lab. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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