Target once distinguished itself as being boldly supportive of the LGBTQ+ community

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The legend and icon John Waters, a mustachioed Maryland man who talked the drag queen

Using existing drugs to treat cervical cancer before standard treatment could lead to a 35% reduction in the risk of relapse or death, a new study suggests. Researchers from the UCL Cancer Institute and UCLH looked into whether a short course of induction chemotherapy (IC), where a drug is used to destroy as many cancer cells as possible, before chemoradiation (CRT), could help with this. Here’s everything you need to know about the findings… What is cervical cancer? According to the NHS website, cervical cancer is a type of cancer found anywhere near the cervix – the opening between the vagina and the womb (uterus), which is also known as the neck of the womb. Most cervical cancers grow very slowly and are caused by an infection from specific types of human papillomavirus (HPV) and mostly affect women under the age of 45. According to Jo’s Cervical Cancer Trust, symptoms include vaginal bleeding that is unusual to you, changes to vaginal discharge, discomfort during sex and pain in your lower back or pelvis. Changes to cells can be spotted by a cervical screening, and then treated before they turn into cancer. There are around 3,200 new cases every year in the UK, with the five-year survival rate being around 70%, according to Cancer Research UK. CRT has been the standard treatment for cervical cancer patients since 1999, but even though there have been overall significant developments in radiation therapy techniques, up to 30% of people experience their cancer coming back. What did the research involve? Over a 10-year period, 500 patients who had been diagnosed with cervical cancer – that was large enough to see without a microscope but hadn’t spread to other parts of the body – took part in the Interlace trial at hospitals in the UK, Mexico, India, Italy and Brazil. Researchers looked into whether a short course of IC before CRT could reduce rates of relapse and death. What results were found? After five years, researchers discovered that 80% of the people who received a combination of chemotherapy and radiotherapy were alive, whilst 73% had not seen their cancer return or spread. A major benefit, according to researchers, is that it can be incorporated into standard of care treatment relatively quickly, because cheap, accessible and already-approved ingredients such as carboplatin and paclitaxel are needed for IC. “Our trial shows that this short course of additional chemotherapy delivered immediately before the standard CRT can reduce the risk of the cancer returning or death by 35%,” said Dr Mary McCormack, lead investigator of the trial from UCL Cancer Institute and UCLH. “This is the biggest improvement in outcome in this disease in over 20 years. “I’m incredibly proud of all the patients who participated in the trial; their contribution has allowed us to gather the evidence needed to improve treatment of cervical cancer patients everywhere. “We couldn’t have done this without the generous support of Cancer Research UK.” Why is the research important? Dr Iain Foulkes, executive director of research and innovation at Cancer Research UK, said: “Timing is everything when you’re treating cancer. The simple act of adding induction chemotherapy to the start of chemoradiation treatment for cervical cancer has delivered remarkable results in this trial. “A growing body of evidence is showing the value of additional rounds of chemotherapy before other treatments like surgery and radiotherapy in several other cancers. “Not only can it reduce the chances of cancer coming back, it can be delivered quickly using drugs already available worldwide. “We’re excited for the improvements this trial could bring to cervical cancer treatment and hope short courses of induction chemotherapy will be rapidly adopted in the clinic.”

Gemma Atkinson has given birth to her second child with Strictly Come Dancing professional dancer Gorka Marquez. The former Emmerdale actor, 38, announced on Instagram that she and her fiancé had welcomed a baby son, whom she called “utterly wonderful”. Writing on her Instagram Stories on Wednesday morning (19 July), Atkinson told her 1.8m followers: “Little man is here! He arrived safe and sound and he’s utterly wonderful. “We’re all home together soaking up this lovely little bubble before Gorks has to leave for Strictly rehearsals next week.” She added: “Thank you for all the lovely well wishes. Our family is complete.” Her partner Marquez shared the same message on his own Instagram page. The couple, who already share a three-year-old daughter, Mia, met when Atkinson appeared on Strictly Come Dancing as a celebrity contestant in 2017. Though they were not coupled up on the dancefloor, the pair started dating after the show wrapped. When Atkinson gave birth to their first child, Mia, in 2019, she needed an emergency c-section and suffered a haemorrhage after the birth, losing nearly a litre of blood. Following the experience she said she was initially “adamant” that she and Marquez would not want another child. “All these things were going through my mind, what did I do that caused all that to happen? I was telling myself for weeks and weeks I’d failed at childbirth,” the actor told Channel 4’s Steph’s Packed Lunch last year. “I was having horrible dreams that someone was going to take Mia from me. I remember my mum running into my bedroom and I was sat up screaming, sweating.” Atkinson added that a woman approached her and her mum when she was out with Mia one day and said: “Oh I believe it [the birth] wasn’t a success was it, you know, what happened?” Atkinson’s mother replied: “It was a huge success, Mia’s there, Gemma’s here, total success.” “Something clicked in me then,” Atkinson said of the exchange. “My body had done me proud because it had recovered and got me through. “I’m at the stage where I want a sister or brother for Mia. The first few months of Mia’s life, I kept saying to my partner, Gorka, ‘I’m not going through that again’. I’ve now come out of it and I feel I could.” According to the Birth Trauma Association (BTA), around 30,000 women per year experience birth trauma in the UK. The radio presenter said at the time that she met with a psychotherapist to learn more about birth trauma and how women can be helped through it. “It was strangely comforting speaking to the women, it makes you feel like you’re not on your own, you’re not the only person who had a difficult labour,” Atkinson added. Read More Influencer Annabelle Ham dies at age 22: ‘A light to the world’ Cruise line apologises after passengers witness dozens of pilot whales being slaughtered Groom sparks backlash over wedding prank he pulled on his bride: ‘Huge red flag’ Nearly half of women feel ‘too unfit’ to enjoy exercise this summer – how to overcome fitness fear Anorexic woman, 47, who wants to die may soon be able to under Canadian law Mindy Kaling shuts down weight loss question as ‘people take it so personally’

Heidi Klum is prepping for the debut of her own creation – her 2023 Halloween costume. From a flesh-eating alien to Fiona and a sparkly firework, the 50-year-old supermodel not only stunts on high-fashion runways but on the red carpet for the spookiest night of the year. It’s safe to say Klum’s love for dressing up isn’t just haute couture. She’s a costume enthusiast as well, and the mother of three is already preparing to assume her character for this year’s Halloween celebration. The America’s Got Talent judge spoke to the MailOnline last week while taping for the show, where Klum hinted at her outlandish costume plans currently in the works. “It’s going to be extra. It’s going to be really extra. I have had sleepless nights over it, you know me,” she confessed. “I have to admit, I love it. And then my gut, I feel like it’s going to be good.” Last year, the German businesswoman shocked spectators by dressing in an all-too-realistic worm get-up, which took two years to make. Only the fashion mogul’s eyes peered through the thick and slimy coating of the cylinder costume. Speaking to the MailOnline, Klum admitted her team conveyed the same concerns over her desired look for this year as they did with her 2022 worm attire. “They were like, ‘A worm, really?’” Klum recalled in conversation with the outlet. “They kind of wanted me to think of a plan B and a plan C, but I’m not like that. For me, it is plan A.” “If you are thinking of all different other things, then it’s not going to be a success or it’s not going to be that major,” she continued. “Everyone around is always like: ‘Think of something different. This is crazy. And the worm is crazy.’” Though Klum’s been known to incorporate her husband and children in the storyline for her 31 October looks, she revealed her 2023 appearance will be a solo act. She admitted: “I never know if it will be good until the day, and I don’t want to let my Halloween fans down. There are so many creative people around the world and I don’t want to let them down.” The TV host has known her costume would only involve herself since 1 November last year, as that’s when she typically starts planning for the following year’s holiday. “When I wake up tomorrow, I start thinking of the next [costume],” Klum told People at her 2022 party. Klum’s bubbly textured invertebrate costume followed her intricate Zombie look and 2020 toilet paper mummy. The producer gravitates toward heavy makeup and facial reconfiguration for accuracy in every character. She’s rarely recognisable on the day, except for her eyes piercing through the thick mask made to look animated for every character. However, the style enthusiast took a break to seemingly celebrate herself in 2016, when she dressed as a Victoria’s Secret angel. Not only did Klum wear a renowned runway look from the intimates brand, but she convinced a squad of other women to mimic her look and reconstruct their facial features to look like her. In 2013, Klum decided to hit the fast-forward function on time and dressed like an old lady. The immaculate prosthetics, which included a wrinkled collarbone and varicose veins lining her neck, crafted a look so realistic that you’d think she was many years past her age - and not the then 40 years old that she was. Read More Heidi Klum denies she counts calories after facing backlash over reports she only eats 900 calories a day Heidi Klum’s model daughter Leni shows off grisly burn after admitting she ‘didn’t use enough sunscreen’ Heidi Klum opens up about her and husband Tom Kaulitz’s 16-year age gap 11 best kids’ Halloween outfits that will scare and delight 9 best horror stories to read this Halloween and beyond Kourtney Kardashian’s skeletons and other celebrity inspiration for Halloween

Kanye 'Ye' West and his rumoured wife Bianca Censori have caused a stir in recent weeks with a series of risqué outfits while travelling Italy. In the latest string of photos, the pair were spotted enjoying a shopping day in Florence. The snaps show the rapper donning his usual all-black attire, including a tee, pants, a hood – and no shoes. Censori, a former Yeezy employee, was seen wearing a sheer, nude bandeau top paired with a pair of black shorts and heels. It comes after Censori was spotted holding a pillow on a day out in Italy after locals complained about her "offensive" outfits. The photos were shared on X/Twitter, with one writing: "How completely ridiculous these people are. Put on some clothes and then you won’t have to take a hotel room cushion out sightseeing with you - and you even get your arms free! Novel concept." Another added: "Kanye & Bianca Censori are unhinged. Someone ought to stage an intervention. Wearing a pillow? Him walking in socks?" The pair were previously banned from a Venice boat company after West exposed his bare bottom to onlookers, while Censori rested her head on his lap. Venezia Turismo Motoscafi has since revealed the couple will "no longer be welcome" on any of their boats. In a statement, the company said staff were "completely unaware" West had dropped his pants, as they were focusing on water traffic. A source for the Venice Police told the Daily Mail : "There are standards of public decorum that have to be followed by tourists and locals alike and any breaches are severely punished. The images of West with his trousers down while in a taxi as he and his partner crossed the lagoon were seen all over the globe." Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

It’s not too late to score big at end-of-summer sales, and Saks Fifth Avenue has a good one. You can get up to 70% off while sprucing up your fall wardrobe with a new black leather jacket or find a shimmering wedding guest dress for a black-tie wedding. The sale section is filled to the brim with the latest minimalistic and bedazzled handbags, cozy sweaters, and everyday jeans. Find our favorite picks ahead. There’s Mansur Gavriel’s popular handbag, an Alice + Olivia silky satin power suit, and trendy pleated skirts from Ralph Lauren. The sale is only available for a limited time and select styles are selling out fast, so get shopping and keep that credit card nearby.

About 50% of Spirit Airlines flights were delayed Thursday, according to FlightAware, after technical issues with the airline's website, app and airport kiosks, but the airline says the technical issues have been resolved.

UPDATE: May. 11, 2023, 5:00 a.m. EDT This story has been updated to include new

A court in Iran has sentenced prominent movie director Saeed Roustaee to six months' prison for the screening of his film "Leila's Brothers" at the Cannes Film Festival...

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