When your luggage goes missing, it's bad enough. Tackling the start of your vacation without your clothes or toiletries? It's not something most of us want to do. But when your luggage itself is the reason you're traveling in the first place, it gets considerably worse.

If Quordle is a little too challenging today, you've come to the right place for

Ocado has reduced prices on more than 100 products as the online grocer attempts to win over shoppers

Apple co-founder Steve Wozniak has been hospitalized, according to numerous outlets. Wozniak was scheduled to

Thousands of 'Penis Fish' have been found on a beach… giving locals the willies. The rude-looking marine creatures appeared after a heavy storm. The pink wrigglers were about 10 inches in length. They freaked out locals in Río Grande, southern Argentina, on the afternoon of 17 July. The species are called Urechis Unicinctus, but they are also dubbed the 'Penis Fish' due to their phallic appearance. Sign up to our free Indy100 weekly newsletter Despite their nickname, the creatures are actually a type of spoonworm. Their other nickname is 'The Fat Innkeeper Worm'. They create U-shaped burrows in sand or mud that are then left for other animals to move into, hence the use of ‘innkeeper’ in its moniker. They are eaten by sharks and seagulls. They usually live underground but are brought to the surface during strong storms, leaving them exposed to predators. Evidence of their U-shaped burrows dates back over 300 million years. The worms, which can live up to 25 years, are a common delicacy in countries such as South Korea, Japan and China where they are eaten raw or cooked in a variety of different styles. They are said to have a chewy texture and are surprisingly sweet, often served with a savoury sauce made from sesame oil or vinegar with gochujang. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Who expected the humble touchpad to be a Computex 2023 star? At its laptop press

GATLINBURG, Tenn.--(BUSINESS WIRE)--Sep 12, 2023--

Singapore’s Changi Airport, ranked the best in the world, saw passenger traffic surge close to pre-pandemic levels last

The brain’s appetite control centre is different in the brains of people who are overweight or live with obesity, a new study suggests. The researchers said their findings add further evidence to the relevance of brain structure to weight and food consumption. Current estimates suggest that more than 1.9 billion people worldwide are either overweight or obese. And, according to the Office for Health Improvement and Disparities, almost two-thirds of adults in the UK are overweight or living with obesity. This increases the risk of developing health issues like type 2 diabetes, heart disease and stroke, cancer and poorer mental health. The last two decades have given us important insights about appetite control and how it may be altered in obesity Professor Paul Fletcher, University of Cambridge A number of factors influence how much people eat and what they eat, including genetics, hormone regulation, and the environment they live in, researchers say. However, it is not entirely clear what happens to the brain to tell us that we are hungry or full. Past studies have shown that the hypothalamus – a small region of the brain about the size of an almond – plays an important role. Dr Stephanie Brown, from the Department of Psychiatry and Lucy Cavendish College, University of Cambridge, said: “Although we know the hypothalamus is important for determining how much we eat, we actually have very little direct information about this brain region in living humans. “That’s because it is very small and hard to make out on traditional MRI brain scans.” Professor Paul Fletcher, the study’s senior author, from the Department of Psychiatry and Clare College, Cambridge, said: “The last two decades have given us important insights about appetite control and how it may be altered in obesity. “Metabolic researchers at Cambridge have played a leading role in this. “Our hope is that, by taking this new approach to analysing brain scans in large datasets, we can further extend this work into humans, ultimately relating these subtle structural brain findings to changes in appetite and eating and generating a more comprehensive understanding of obesity.” The majority of evidence for the role of the hypothalamus in appetite regulation comes from animal studies, which indicate complex interacting pathways within the hypothalamus, with different cell populations acting together to tell us when we are hungry or full. To get around this researchers used an algorithm developed using machine learning to analyse brain scans taken from 1,351 young adults across a range of BMI scores. They looked for differences in the hypothalamus when comparing individuals who are underweight, healthy weight, overweight, or living with obesity. According to the findings, the overall volume of the hypothalamus was significantly larger in the overweight and obese groups of young adults. The researchers describe a significant relationship between volume of the hypothalamus and body mass index (BMI). The differences were most apparent in those sub-regions of the hypothalamus that control appetite through the release of hormones to balance hunger and fullness. While the exact significance of the finding is unclear, one explanation is that the change relates to inflammation, the researchers suggest. Eating a high-fat diet could trigger inflammation of our appetite control centre Dr Stephanie Brown, University of Cambridge Previous animal studies have shown that a high-fat diet can cause inflammation of the hypothalamus, which in turn prompts insulin resistance and obesity. In mice, just three days of a fat-rich diet is enough to cause this inflammation. Other studies have shown that this inflammation can raise the threshold at which animals are full – in other words, they have to eat more food than usual to feel full. Dr Brown added: “If what we see in mice is the case in people, then eating a high-fat diet could trigger inflammation of our appetite control centre. “Over time, this would change our ability to tell when we’ve eaten enough and to how our body processes blood sugar, leading us to put on weight.” More research is needed to confirm whether increased volume in the hypothalamus is a result of being overweight or whether people with larger hypothalami are predisposed to eat more in the first place. It is also possible that these two factors interact with each other, causing a feedback loop, the study published in Neuroimage: Clinical, and supported by the Bernard Wolfe Health Neuroscience Fund, Wellcome and the NIHR Cambridge Biomedical Research Centre, with additional funding from Alzheimer’s Research UK, suggests.

EAST RUTHERFORD, N.J. & SEATTLE--(BUSINESS WIRE)--Jul 19, 2023--

UK retail sales rose unexpectedly in May, indicating strength in the economy that the Bank of England fears

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