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A new survey has found that nearly half of adults in the United States are interested in taking prescription drugs for weight loss, such as Ozempic or Wegovy. In a KFF health tracking poll published on 3 August, researchers reported that 45 per cent of adults said they’d be interested in taking a “safe and effective” prescription drug for weight loss. Meanwhile, seven in 10 adults said they’ve heard at least “a little” about a new class of drugs being used for weight loss, with about one in five saying they have heard “a lot” about these drugs. Ozempic is a type 2 diabetes medication known for its weight loss side effects. Similar semaglutide injections, such as Wegovy and Mounjaro, have been specifically approved for the treatment of obesity and weight loss. This class of drugs called GLP-1 agonists works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), regulating blood sugar levels and slowing down the rate at which food leaves the stomach to create the feeling of fullness. Of the US adults surveyed, older groups were some of the most aware of prescription weight loss drugs, with 76 per cent being those who have been told by a doctor in the past five years that they are overweight or obese. Nearly 60 per cent of those surveyed said they were currently trying to lose weight as well. While there was an overall interest in taking a prescription weight loss drug, that interest significantly decreased when people were asked whether they would take the medication as a routine injection. Only 16 per cent of adults said they would still take Ozempic or Wegovy, even if it wasn’t covered by their health insurance and was not specifically approved by the US Food and Drug Administration for weight loss. In fact, most people believed that insurance companies should cover the cost of weight loss drugs for adults who are overweight or obese, with an overwhelming 80 per cent of adults. Additionally, a large majority of adults believed the substantial profits that pharmaceutical companies have made from increased demand for weight loss drugs is a major factor contributing to the cost of injections like Ozempic and Wegovy. According to Novo Nordisk, the pharmaceutical company behind these prescription drugs for diabetes and weight loss, the list price for Ozempic can cost $935.77 per month without health insurance. Although the majority of adults said they trust pharmaceutical companies like Novo Nordisk to provide “reliable information” about safety and side effects of GLP-1 agonists, only 22 per cent said they trust these companies to price their products fairly. The FDA has listed the most common side effects of taking Wegovy as nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, and digestive disorders. More serious complications can occur from use of Wegovy or Mounjaro, such as the “potential risk of thyroid C-cell tumours,” pancreatitis, gallbladder problems, acute kidney injury, increased heart rate, and suicidal behaviour or thinking. Taking Ozempic can also lead to possible thyroid tumours, including cancer, pancreatitis, changes in vision, and kidney and gallbladder problems. Recently, several patients reported suffering from severe gastroparesis, also known as stomach paralysis, after taking the prescription weight loss medications. In a report from CNN, two people claimed that their “stomachs are paralysed” after taking Ozempic. “I wish I never touched it. I wish I’d never heard of it in my life,” Joanie Knight, a 37-year-old from Louisiana, told CNN. “This medicine made my life hell. So much hell. It has cost me money. It cost me a lot of stress; it cost me days and nights and trips with my family. It’s cost me a lot, and it’s not worth it. The price is too high.” One woman was also diagnosed with cyclic vomiting syndrome, which causes her to throw up multiple times a day. “I’ve almost been off Ozempic for a year, but I’m still not back to my normal,” said Emily Wright, a 38-year-old teacher from Toronto. Shortly after the report, the FDA shared in a statement with The Independent that it has become aware of stomach paralysis occurring among patients taking the medications. “The FDA has received reports of gastroparesis with semaglutide and liraglutide, of which some documented the adverse event as not recovered after discontinuation of the respective product at the time of the report,” the agency said. However, officials clarified that they were unable to determine whether taking Ozempic or Wegovy was the cause of stomach paralysis, or if it was caused by a different issue. “Gastroparesis can be a complication of diabetes that is related to long-standing or poorly controlled disease, further complicating the ability to determine what role the drugs played in the reported events,” the FDA added. In response to reports of stomach paralysis, drug manufacturer Novo Nordisk noted that these medications have been used to treat type 2 diabetes “for more than 15 years”, and for the “treatment of obesity” for eight years. “Semaglutide has been extensively examined in robust clinical development programs, large real world evidence studies and has cumulatively over 9.5 million patient years of exposure,” a spokesperson for Novo Nordisk said in a statement to The Independent. “Gastrointestinal (GI) events are well-known side effects of the GLP-1 class. For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration. GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects.” Read More Obese people on weight-loss jabs ‘should be prepared to stay on them for life’ Ozempic users report stomach paralysis as weight loss drug side effect: ‘I wish I never touched it’ Sharon Osbourne says she was ‘nauseous’ for weeks after taking Ozempic to lose weight Sharon Osbourne reveals what Ozempic did to her when she was taking it Ozempic users report stomach paralysis as side effect: ‘I wish I never touched it’ Lorraine Candy: ‘Perimenopausal rage made me unravel’

With so much of the gorgeous countryside on our doorsteps, or a train ride away unexplored, we all are looking for new ways to get out and about. Trail running could be the adventurous workout that helps us do just that, as it combines hillwalking, running and hiking, taking runners to remote corners of the planet, and travelling the world in their trainers. With sports brands like Nike, Salomon and Vivobarefoot placing an increasing emphasis on their trail options for runners, and a gradual increase in Google searches for ‘trail running’ over the past five years, what actually is it? “Technically speaking, trail running is a form of running that takes place on varied terrains, away from paved paths or tracks,” says Jodie Gauld, run leader for Love Trails Festival. “However, it’s so much more, it’s a special feeling and a welcoming community.” The benefits “I find trail running very calming, and my focus will be very present. You’re typically in nature, so rather than modern distractions like cars, bustling streets and flashing signs, you can instead be in the moment of your running and in awe of your surroundings, which can give life a new perspective on what really matters,” Gauld reflects. There is less focus on speed and more on experience. “Trail running can also be very playful. It’s typically less serious, because the nature of running over varying terrains and up and down different gradients, means pacing and timing are less controllable or comparable,” she says. “Then, even if you hit a path with a good rhythm, you still have to concentrate, because there could be obstacles. You can hit an ultimate high – your focus becomes super-zoned, while your pace is good and you feel like you’re flying.” It’s easy to find community in trail running, because it’s an equaliser. “Because trail running is less about pace, it’s really inclusive. Seriously, if you do a trail race, the first question won’t be about your time, it’ll be about your experience,” says Gauld. “These factors and so many more, mean that trail running attracts a wonderful, supportive community. I’ve run all my life and have been knowingly trail running for over a decade, and don’t think I’ve ever met another trail runner who hasn’t been encouraging and friendly.” The required kit “While road shoes will be fine on hard-packed trails, you’ll get even more fun with a pair of trail shoes. Trainers specifically designed for the trails will have grip for the varying terrains, and will save you slipping around,” Gauld continues. When looking for the right shoes, Ben Le Vesconte, head coach at Vivobarefoot says “Look for wide toe boxes which allow your toes to spread, to ensure you remain balanced and stable on the trail.” Next, he recommends looking for thin soles, so you can feel the trail underneath your feet. “It will help you feel the changing terrain, allowing you to react quickly and improve your stability. The more cushioning you add, the less you feel. “Think about the grip you choose, typically thicker and longer lugs [small points of raised rubber lining the outsole] are best for muddy terrain, with smaller lugs best for firmer terrain. If it’s wet weather or waterlogged terrain, you want a shoe that drains well and for the heat, it should be very breathable,” he explains. Your kit is more important than it is for road running, because you’re likely to be away from access to help, and there are more things that can potentially go wrong. “With this in mind, I typically take my running vest or a hydration pack, no matter how short the distance, in which I’ll pack my phone – for photos but also safety – water, snacks, a foil blanket, a basic first aid kit, a waterproof and possibly spare layers,” says Gauld. “I also have a GPX watch, mainly for the mapping tools, but this is expensive, and there are loads of accessible mapping apps on phones now.” The risks “In a lot of trail races, there will be a kit list – this will be for safety reasons and encourages respect in nature where the conditions can change very quickly. I started a race in nearly 30-degree heat, and within just a few hours, we were in hypothermic conditions and hail storms. I finished that race – while others more experienced than me dropped out – because I had all the kit,” Gauld reveals. “Of course, like any activity, there are things to be wary of. When you’re starting, take your time and get used to the uneven and varied terrain,” says Matt Buck, a trail running coach, owner of Running Adventures and guide runner for Love Trails Festival. “Make sure you take a friend, or at the least tell someone where you are going, and always have a phone on you in case you need to call for help. Take it slow, and you will be fine.”

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