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Lewis Hamilton had hoped his revamped Mercedes would have propelled him closer to the front after he finished sixth in practice for Sunday’s Monaco Grand Prix. Hamilton’s Mercedes team arrived for the sixth round of the season in the sun-cooked principality armed with a major upgrade. But after an encouraging start – with Hamilton briefly heading the order in the opening running of the weekend – the British driver ended the day half-a-second behind Max Verstappen, who finished fastest for Red Bull. George Russell was only 12th in the other Mercedes. “It is a shame we were not as close as I hoped we would be at the end of the session,” said Hamilton. “In P1, I thought, ‘Wow, maybe we’re looking pretty good’, but in P2 we were close to half-a-second off. I don’t think we have half a second in the bag. “We’ve just got to keep chipping away to see if we can squeeze any more juice out of the cup.” After giving up on this season’s car on the eve of the opening race in Bahrain, Mercedes have spent the ensuing dozen weeks working on a new design philosophy. The Silver Arrows have abandoned their controversial zero-sidepod concept and introduced a new front suspension, new floor and cooling system in a drastic change of development on a car which has contributed to the longest losing streak of Hamilton’s career. On Sunday, it will be 539 days since Hamilton last stood on the top step of the podium at the penultimate round of the contentious 2021 season in Saudi Arabia. And although Mercedes are keen not to draw too many conclusions at this week’s unique Monte Carlo configuration – and believe the following round at the well-trodden Circuit de Catalunya venue on the outskirts of Barcelona will present them with a better understanding of where they stand – the evidence of practice suggests they are no closer to providing a real challenge to Red Bull. Hamilton added: “It’s not really the place to test an upgrade, but the car was generally feeling good. “It’s very clear where the lack of performance is, and we will talk about that in the debrief. Hopefully this gives us a platform to build on moving forwards.” Verstappen and team-mate Sergio Perez are the only men to have won a race this year, but their rapid Red Bull is not necessarily suited to the narrow and slow-speed track in Monaco. However, despite Perez managing only seventh in practice, Verstappen’s pace indicates he could still be the driver to beat. Home favourite Charles Leclerc is ready to pounce – after he finished just 0.065 seconds back – with his Ferrari team-mate Carlos Sainz, who crashed out of second practice remaining following a mistake at the high-speed swimming pool chicane, third. Fernando Alonso could be a contender, too. The Aston Martin driver, 41, took fourth spot, 0.220 sec adrift of Verstappen. Lando Norris finished fifth in his McLaren. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Lewis Hamilton: Racist abuse of Vinicius Junior really hits home for me Bernie Ecclestone would be surprised if Lewis Hamilton wanted to leave Mercedes Lewis Hamilton insists right decision is made as Emilia Romagna GP cancelled

US lawmakers can now wear hoodies and whatever else they choose in the Senate gallery.

I have fond childhood memories of the preparation process involved in making this cake,” says Maria Bradford, author of Sweet Salone. “We would often cream the butter and sugar by hand using a wooden spoon in Sierra Leone and this could take hours, but the end result was worth it. The next step is where Sierra Leonean ingenuity comes in. We would butter the inside of empty powdered milk tins and use these as baking tins. “The cake was then baked outside in the open on an improvised oven, with a large pot placed on top of three stones, with sand spread across the base. We put the cake tins on top of the hot sand in the pot and put the lid on. Our fuel was wood or charcoal, and when the fuel was very hot, we put lumps of hot charcoal on top of the lid of the pot to brown both the top and bottom of the cake.” Sierra Leonean-style rich cake Serves: 6-8 Ingredients: 150g butter, plus extra for buttering 150g caster sugar 3 eggs 50g plain flour 150g self-raising flour 1-2tbsp full-fat milk Finely grated zest of 1 orange 1 tsp natural orange flavouring (I use Steenbergs’ Organic Orange Extract) Method: 1. Make sure all the ingredients are at room temperature. Generously butter an 18-centimetre cake tin. Preheat the oven to 180C/160C fan/350F/gas mark 4. 2. Using an electric hand-mixer, cream the butter and sugar together in a large mixing bowl until the mixture is pale, light and fluffy (10-15 minutes). Don’t rush this step; the more thoroughly the butter and sugar are combined, the lighter the cake will be. Add the eggs, one at a time, beating the mixture well between each addition. Add one tablespoon of flour with the last egg to prevent curdling. 3. Sift both flours into the bowl and gently fold in, adding just enough milk to give a mixture that drops slowly from a spoon when the spoon is held away from the bowl. Fold in the orange zest and orange flavouring. 4. Pour the batter into the prepared tin and bake for 30-40 minutes, or until golden-brown on top and a skewer inserted into the centre comes out clean. 5. Turn the cake onto a cooling rack and leave to cool. Slice and enjoy. ‘Sweet Salone’ by Maria Bradford (Quadrille, £30). Read More A week’s worth of summery recipes (even when the weather is dire) The dish that defines me: Frank Yeung’s prawn wontons Discovering Sierra Leonean flavours in South London How to make cassava chips How to make West African brasied beef shorts in peanut and coconut milk In Horto: Hearty, outdoorsy fare in a secret London Bridge garden

MONTREAL--(BUSINESS WIRE)--Aug 3, 2023--

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A recent investigation has found that some Ozempic and Wegovy patients suffered from severe gastroparesis, also known as stomach paralysis, after taking the medications. In a report from CNN published on 25 July, two patients reported that their “stomachs are paralysed” after taking type 2 diabetes drug Ozempic – a semaglutide injection known for its weight loss side effects. “I wish I never touched it. I wish I’d never heard of it in my life,” Joanie Knight, a 37-year-old from Louisiana, told CNN. “This medicine made my life hell. So much hell. It has cost me money. It cost me a lot of stress; it cost me days and nights and trips with my family. It’s cost me a lot, and it’s not worth it. The price is too high.” Emily Wright, a 38-year-old teacher from Toronto, said she vomits so frequently that she had to take a leave of absence from her job. “I’ve almost been off Ozempic for a year, but I’m still not back to my normal,” she said. According to CNN, both women have been diagnosed with severe gastroparesis, a disorder that slows or stops the movement of food from the stomach to the small intestine, per the Mayo Clinic. Wright has also been diagnosed with cyclic vomiting syndrome, which causes her to throw up multiple times a day. Meanwhile, one Wegovy user claimed she began experiencing stomach problems after her doctor prescribed her the weight loss drug – which works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), regulating blood sugar levels and slowing down the rate at which food leaves the stomach to create the feeling of fullness. However, the medication caused her to vomit so much that she became dehydrated and needed to visit urgent care. Brenda Allen, from Texas, has since been managing her nausea and vomiting with a medication called Zofran and prescription probiotics. Now, the US Food and Drug Administration has said they’ve received reports of stomach paralysis among patients taking the medications. “The FDA has received reports of gastroparesis with semaglutide and liraglutide, some of which documented the adverse event as not recovered after discontinuation of the respective product at the time of the report,” the agency said in a statement to CNN. However, officials clarified that they were unable to determine whether taking Ozempic or Wegovy was the cause of stomach paralysis, or if it was caused by a different issue. “Gastroparesis can be a complication of diabetes that is related to long-standing or poorly controlled disease, further complicating the ability to determine what role the drugs played in the reported events,” they said. As for whether patients should be warned about taking the drugs, the FDA maintained that taking the medications, such as for treating diabetes or weight management, may still “outweigh the risks in some patients with gastroparesis or delayed gastric emptying”. In response to reports of stomach paralysis, Novo Nordisk – the manufacturer behind Ozempic and Wegovy – noted that these drugs have been extensively studied in the real world and in clinical trials. “Gastrointestinal (GI) events are well-known side effects of the GLP-1 class,” the company told CNN. “For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration. GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects.” Last week, the American Society of Anesthesiologists also issued a warning that those who take GLP-1 agonists should avoid the medications a week before surgery because they may increase “risk of regurgitation and aspiration of food” while under anesthesia and deep sedation. Ozempic, a once-weekly injection used for the treatment of type 2 diabetes, has skyrocketed in use after people were reportedly prescribed the FDA-approved diabetes medication as an “off-label” weight loss drug. However, because of its increasing popularity, it has led to national shortages of the diabetes treatment - leaving those who actually need Ozempic without it. Meanwhile, Wegovy and Mounjaro are popular once-weekly semaglutide injections specifically approved for the treatment of obesity and weight loss. There are many side effects of taking medications like Ozempic, Wegovy, and Mounjaro. According to the FDA, the most common side effects of taking Wegovy are nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, and digestive disorders. The FDA has also warned about more serious complications that can occur from use of Wegovy or Mounjaro, such as the “potential risk of thyroid C-cell tumours,” pancreatitis, gallbladder problems, acute kidney injury, increased heart rate, and suicidal behaviour or thinking. Taking Ozempic can also lead to possible thyroid tumours, including cancer, pancreatitis, changes in vision, and kidney and gallbladder problems. The Independent has contacted Novo Nordisk and the FDA for comment. Read More Clinics told to stop prescribing medicines as weight loss drug hits diabetes supply Influencer addresses ‘dangers’ of complimenting people’s bodies after weight loss comments Ozempic under EU investigation over reports of suicidal thoughts Mindy Kaling shuts down weight loss question as ‘people take it so personally’ What are weight loss injections and what’s the controversy? Raven Symone says people shouldn’t use Ozempic for ‘glamazon purposes’