A recent investigation has found that some Ozempic and Wegovy patients suffered from severe gastroparesis, also known as stomach paralysis, after taking the medications. In a report from CNN published on 25 July, two patients reported that their “stomachs are paralysed” after taking type 2 diabetes drug Ozempic – a semaglutide injection known for its weight loss side effects. “I wish I never touched it. I wish I’d never heard of it in my life,” Joanie Knight, a 37-year-old from Louisiana, told CNN. “This medicine made my life hell. So much hell. It has cost me money. It cost me a lot of stress; it cost me days and nights and trips with my family. It’s cost me a lot, and it’s not worth it. The price is too high.” Emily Wright, a 38-year-old teacher from Toronto, said she vomits so frequently that she had to take a leave of absence from her job. “I’ve almost been off Ozempic for a year, but I’m still not back to my normal,” she said. According to CNN, both women have been diagnosed with severe gastroparesis, a disorder that slows or stops the movement of food from the stomach to the small intestine, per the Mayo Clinic. Wright has also been diagnosed with cyclic vomiting syndrome, which causes her to throw up multiple times a day. Meanwhile, one Wegovy user claimed she began experiencing stomach problems after her doctor prescribed her the weight loss drug – which works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), regulating blood sugar levels and slowing down the rate at which food leaves the stomach to create the feeling of fullness. However, the medication caused her to vomit so much that she became dehydrated and needed to visit urgent care. Brenda Allen, from Texas, has since been managing her nausea and vomiting with a medication called Zofran and prescription probiotics. Now, the US Food and Drug Administration has said they’ve received reports of stomach paralysis among patients taking the medications. “The FDA has received reports of gastroparesis with semaglutide and liraglutide, some of which documented the adverse event as not recovered after discontinuation of the respective product at the time of the report,” the agency said in a statement to CNN. However, officials clarified that they were unable to determine whether taking Ozempic or Wegovy was the cause of stomach paralysis, or if it was caused by a different issue. “Gastroparesis can be a complication of diabetes that is related to long-standing or poorly controlled disease, further complicating the ability to determine what role the drugs played in the reported events,” they said. As for whether patients should be warned about taking the drugs, the FDA maintained that taking the medications, such as for treating diabetes or weight management, may still “outweigh the risks in some patients with gastroparesis or delayed gastric emptying”. In response to reports of stomach paralysis, Novo Nordisk – the manufacturer behind Ozempic and Wegovy – noted that these drugs have been extensively studied in the real world and in clinical trials. “Gastrointestinal (GI) events are well-known side effects of the GLP-1 class,” the company told CNN. “For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration. GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects.” Last week, the American Society of Anesthesiologists also issued a warning that those who take GLP-1 agonists should avoid the medications a week before surgery because they may increase “risk of regurgitation and aspiration of food” while under anesthesia and deep sedation. Ozempic, a once-weekly injection used for the treatment of type 2 diabetes, has skyrocketed in use after people were reportedly prescribed the FDA-approved diabetes medication as an “off-label” weight loss drug. However, because of its increasing popularity, it has led to national shortages of the diabetes treatment - leaving those who actually need Ozempic without it. Meanwhile, Wegovy and Mounjaro are popular once-weekly semaglutide injections specifically approved for the treatment of obesity and weight loss. There are many side effects of taking medications like Ozempic, Wegovy, and Mounjaro. According to the FDA, the most common side effects of taking Wegovy are nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, and digestive disorders. The FDA has also warned about more serious complications that can occur from use of Wegovy or Mounjaro, such as the “potential risk of thyroid C-cell tumours,” pancreatitis, gallbladder problems, acute kidney injury, increased heart rate, and suicidal behaviour or thinking. Taking Ozempic can also lead to possible thyroid tumours, including cancer, pancreatitis, changes in vision, and kidney and gallbladder problems. The Independent has contacted Novo Nordisk and the FDA for comment. Read More Clinics told to stop prescribing medicines as weight loss drug hits diabetes supply Influencer addresses ‘dangers’ of complimenting people’s bodies after weight loss comments Ozempic under EU investigation over reports of suicidal thoughts Mindy Kaling shuts down weight loss question as ‘people take it so personally’ What are weight loss injections and what’s the controversy? Raven Symone says people shouldn’t use Ozempic for ‘glamazon purposes’

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Montana Brown has revealed that she chose to have a home birth when welcoming her son Jude last month because she felt that hospitals are not “the safest place” for non-white people. The former Love Island star, 27, shared a YouTube vlog about her pregnancy and birth plan recently to answer questions from followers about her experience. She opened up about her decision to have a home birth, adding that she hired a doula, a trained professional who supports women through labour and birth, as well as through post-partum. Brown, who is mixed race and has Japanese and Jamaican heritage, said she “can’t wait” for her home birth. She filmed her vlog before giving birth to Jude in June. “I feel like hospital isn’t the safest place to give birth and I know people are gonna be like, ‘What the f***, you’re an idiot’ but I just think it’s personal preference,” she told her followers. “Also, I just think as a non-white person, it’s not the safest place to be in hospital in childbirth. All these things I’ve thought about for a long time. We’re also having a doula, which I’m really excited about.” In the UK, Black women are nearly four times more likely to die in pregnancy and childbirth than white women, according to a report published by MBRRACE-UK (Mothers and Babies: Reducing Risk through Audits and Confidential Enquiries across the UK) in 2022. The study found that there was a slight drop in the maternal mortality rate for Black women between 2018 and 2020. It also found that Asian women are around twice as likely to die in pregnancy and childbirth than white women. In a 2021 response, the government said it was “committed to reducing disparities in health outcomes and experience of care”. Brown, who is engaged to fiancé Mark O’Connor, said she asked for advice on a home birth from The Only Way Is Essex (Towie) star Sam Faiers, who she called the “queen of home birthing”. “It’s just fantastic… She’s helping me feel really set in my decision,” she said. Replying to a fan who asked if she felt afraid of giving birth, Brown said had the “most positive mindset ever”, and would continue to do so even if she had to have a “C-section, an epidural, or wound up in hospital”. The reality star and her fiancé welcomed baby Jude on 23 June. Last week, she opened up about the struggle to get pregnant despite being in her twenties and said she was surprised it took her so long to conceive. Speaking on the Happy Mum Happy Baby podcast, Brown told host Giovanna Fletcher that she thought “something was wrong” with her when she and O’Connor first started trying for a baby. “I thought, ‘We’re young, this is going to be really easy’… For the first four months, we’d used ovulation sticks, and then I’d do a pregnancy test and it’d be negative,” she recalled. After both she and her partner went to check their fertility, they discovered she had “no oestrogen and no testosterone”, which made her realise that people “can be young, fit and healthy, and still really, really struggle to conceive”. Announcing her son’s birth, Brown shared a black-and-white photograph of the newborn being cradled against her chest on Instagram and wrote: “Welcome to the world Jude Isaiah O’Connor. We’re so smitten with you little man.” The couple announced their engagement in April, after O’Connor proposed to her in Bermuda. They first met in 2020. Brown featured in series three of Love Island and was coupled up with Alex Beattie at the end. They broke up shortly after leaving the villa. Read More Ruth Handler: The Barbie inventor who revolutionalised prosthetic breasts and narrowly avoided prison Woman praised for response to airline employee who asked her to swap first class seat with child Fans defend Prince Harry and Meghan Markle amid breakup rumours 8 healthy habits to help you live longer – according to a new study The bowel cancer symptom George Alagiah wished he’d caught earlier George Alagiah: What are the signs of bowel cancer?

Finding a decent pint of Guinness in London can all too often be a disappointing quest, from sour or bitter to poorly poured pints in plastic cups with bubbly heads. Some even say London is where Guinness goes to die. For those who feel they should at least enjoy drinking the pint they’ve paid ludicrous prices for, here’s a small, non-exhaustive and open-ended list of London pubs where you’re more or less guaranteed a scrumptious pint of what my friends and I call Guinny Jones. I’d like to add a disclaimer that I’m not an expert – though I am a quarter Irish and have taken the Guinness factory tour in Dublin – I just really, really like a good pint. So, I spoke to Ian Ryan, who runs an Instagram account dedicated to the capital’s crimes against the black stuff (@shitlondonguinness) and though he isn’t exactly short on blasphemous submissions, he’s also got a lot of insight into what makes a good pint and where to find it. Plus, Ian has a book coming out in October, A Beautiful Pint: One man’s search for the perfect pint of Guinness - he cares about the cause. Before we get to the pubs, here’s what we’re looking for in a pint. Texture: it should have a texture that withstands the “tilt test”, if you tip your glass slightly to the side and the head starts dripping down the side, it’s too watery. It should rise just above the edge of the glass in an oh-so-satisfying manner. Taste: Guinness has a malty sweetness and bitter hoppines, but it shouldn’t be too bitter, nor should it be sour. It should be rich and creamy, with slight aromas of coffee. If it tastes metallic, run for the hills. Head: a good pint of Guinness needs that signature creamy head. Ideally, it’ll be domed and around three-quarters of an inch. This is essential for balance and flavour. Also, if the head is littered with bubbles, it means it hasn’t been properly aerated and will almost definitely taste bad. Pour: according to Guinness Storehouse it should, of course, be in a Guinness or milk stout glass – it’s just wrong drinking out of a Stella or Beavertown. It should then be poured at a 45-degree angle up to the harp and then left to settle for at least a minute, but up to two if possible. It’s finished by topping up with the glass held straight. Red flags: according to Ryan, any sort of bubbles in the head are a big no-no. “Also, if you walk into a pub and no one is drinking Guinness, it could be a sign of bad things to come…” The Auld Shillelagh, 105 Stoke Newington Church Street, London, N16 0UD This Irish pub is most die-hard Guinness fan’s favourite London establishment, Ryan included. It looks tiny and unassuming from the outside but its narrow interior stretches far back into a surprisingly spacious garden. They have live music, great craic and, of course, perfect pints of Guinness. The best thing about the Shillay is that it doesn’t try too hard, which means it ends up absolutely nailing the pub formula. The Irish Times even named it the “most authentic Irish pub in the world outside Ireland”. If that doesn’t convince you, I don’t know what will. The Globe, 20 Morning Lane, London, E9 6NA A pub where you can enjoy Spoons prices without Spoons guilt, The Globe is a local’s pub through and through, but they’re also incredibly welcoming to newcomers. They’ve got live sports, pool, darts, karaoke, live music and pints of Guinness that pass the test at around the £4 mark, for zone 2, that’s practically unheard of. The Coach and Horses, 42 Wellington Street, London, WC2E 7BD Not far from Covent Garden piazza, The Coach and Horses is just far enough off the beaten track to not be inundated as most pubs in central are. This one-room Irish pub was once voted as the best Guinness in Britain by The Irish Post, plus they also sell hot roast beef sandwiches. Gibney’s London, 70 City Road, London, EC1Y 2BJ Staying open until 2am on a Friday, Gibney’s is an Irish pub based in the heart of Shoreditch. Upstairs they have “inventive small plates, Irish meats cooked over the open flame, fresh seafood and more from chef Richard Corrigan”, while downstairs they have Shit London Guinness-approved pints. The Cock Tavern, 23 Phoenix Road, London, NW1 1HB An unpretentious pub that prides itself on not being trendy, The Cock Tavern is a delight for both locals and tourists due to its proximity to Euston. Described by one reviewer as an “oasis of humour, personality and character” in the big city and endorsed by SLG, this rough-and-ready establishment knows how to pour a pint and provide good times. The Sheephaven Bay, 2 Mornington Street, London, NW1 7QD An “Irish bar with a conservatory, beer garden and no less than seven plasma screens for showing sports”, The Sheephaven Bay is easily the best Guinness in Camden. Lively atmosphere and friendly staff, what’s not to like? The Kenton Pub, 38 Kenton Road, London, E9 5BA Most of the pubs listed have unsurprisingly been of the Irish variety, so to throw a curve ball into the mix is the Kenton, a Norwegian pub in Hackney. There’s loads of cosy nooks and crannies, occasional DJs on a Saturday and the fantastic staff all pride themselves on pouring a proper pint. I asked general manager Morgan Ryan about what the secret to serving great Guinness is: “There’s not really a trick to it if you’ve ever poured a pint. Don’t buy old kegs, don’t store them badly and don’t have dirty ass lines.” Read More Marina O’Loughlin is wrong – there’s joy in solo dining Budget Bites: Three recipes to keep food bills down before pay day Meal plan: Romesco chicken and other recipes to fall in love with The chef who hated food as a child Who knew a simple flan could be so well-travelled? Midweek comfort food: Singaporean curry sauce and rice

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