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Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

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This is one of those brilliant I-can’t-believe-it-was-so-quick dishes that comes together in under an hour,” says chef and Great British Menu host Andi Oliver. “The fragrant broth is packed with succulent prawns.” Aromatic shrimp curry Serves: 4 Ingredients: 450g king prawns, peeled and deveined For the green seasoning marinade: 2 jalapeños, or other chillies of your choice, finely chopped 2 tbsp chopped chives 1 tbsp green seasoning (see below) Pinch each of salt and freshly ground black pepper For the curry sauce: 1 tbsp rapeseed oil 2 onions, very thinly sliced 2 garlic cloves, grated 1 red chilli, chopped 2 tsp ground cumin 2 tsp ground coriander 2 tsp ground turmeric 2 tbsp Caribbean curry powder 1 tsp ground cinnamon 1 tbsp tamarind chutney (see below) 1 tomato, finely chopped 1 x 400ml can of coconut milk Chopped coriander and/or fresh chilli, to serve For the green seasoning: 2 sprigs of thyme 10g fresh bay leaves 1 small bunch of flat-leaf parsley 1 small bunch of coriander 4 spring onions 10 garlic cloves, peeled 1 green chilli or 1 Scotch bonnet, depending on how much heat you like 6 little Caribbean seasoning peppers (about 20g), or a mix of red, yellow, and/or green mini sweet peppers ½ white onion 400ml cold pressed rapeseed oil or any neutral oil Salt and freshly ground black pepper For the tamarind chutney: 4 tbsp tamarind paste 2 tbsp sugar (demerara or dark soft brown sugar work best) 2 tsp coriander seeds 2 tsp ground allspice 2 tbsp green seasoning Airtight jar or container Method: 1. To make the green seasoning, add all the ingredients to a food processor and season to taste with salt and pepper. Whizz to the consistency of a salsa verde and keep in an airtight jar in the fridge for up to two to three weeks. 2. To make the tamarind chutney, put all the ingredients into a small saucepan with 80 millilitres of water. Set over a medium–low heat and warm through, stirring now and again, until everything is melted and combined. Leave to cool, then transfer to a sealed jar or container and store in the fridge to use as needed. The chutney should keep well for three to four weeks. 2. Put the prawns in a medium bowl and add all the marinade ingredients. Mix well and rub the marinade into the prawns with your hands so that all the prawns are well coated. Refrigerate and leave to marinate for about 20 minutes. 3. Meanwhile, to make the curry sauce, get a medium, high sided frying pan over a low–medium heat and pour in the oil. When the oil is hot, add the onions and cook down for 10–15 minutes until soft and fragrant. Add the garlic and chilli and cook for a further three minutes. 4. Add the cumin, coriander, turmeric, curry powder, and cinnamon to the pan and cook, stirring, for one minute. Add the tamarind chutney, chopped tomato, coconut milk and 350 millilitres of water. Bring to a steady simmer for five minutes. 5. Heat a griddle pan or a heavy-based frying pan until red hot, then chuck on the marinated prawns, cooking on each side for around two minutes until nicely charred all over. Transfer the prawns to the curry sauce and simmer for around four minutes to bring it all together. Finish the curry with a sprinkling of some freshly chopped coriander and/or chillies. Serve with roti or plain or coconut rice. Recipe from ‘The Pepperpot Diaries: Stories From My Caribbean Table’ by Andi Oliver (published by DK, £27; photography by Robert Billington). Read More What is coronation chicken? The story of the royal recipe and how to make it Easy coronation chicken pie recipe chosen by Mary Berry Andi Oliver on turning 60 and channeling her anger into power Andi Oliver: Earl Grey tea bags are a gamechanger for barbecue chicken Caribbean-inspired coconut and lime cheesecake Three one-pot recipes for washing up hater

The season two premiere of And Just Like That brought back a familiar face for many loyal Sex and the City fans, and no, it wasn’t the upcoming cameo from actor Kim Cattrall as Samantha Jones. The second season of And Just Like That, which debuted on Max on Thursday 22 June, saw the return of Carrie Bradshaw’s beloved Vivienne Westwood wedding gown, which she wore to her failed wedding to Mr Big (Chris Noth) in the 2008 Sex and the City movie. When Sarah Jessica Parker was photographed wearing the fan-favourite bridal gown in the streets of New York City last November, many fans wondered the reason for its reprise. Now, the season two premiere has revealed that Carrie dons the flowing gown to none other than the Met Gala. Warning: Spoilers ahead In the season two premiere, Carrie works with an up-and-coming designer named Smoke (Bethlehem Million) to create a custom design for the annual fashion event, themed “Veiled Beauty”. But when things go awry, the columnist resorts to her fashion archive and pulls the wedding dress out of her closet. “I may have something,” Carrie tells Smoke during the episode. “I’ve only worn it once. It’s not the best memory.” She even decides to wear the same bird-like headpiece that she wore to her wedding, but this time pairing it with teal gloves, teal heels, and a matching teal cape that Smoke had made. Although wearing the same wedding gown twice may seem like bad luck to some, Parker revealed how the new season of And Just Like That was able to give the dress “new life”. In an interview with People, Parker detailed how she and And Just Like That showrunner Michael Patrick King wanted to change the narrative surrounding the iconic dress by breaking it out for season two. “How would it become something else?” the actor told People. “How would we layer it and give it a new life and have it feel modern and change the poetry that surrounded that dress from a lot of really painful but important memories that I don’t think Carrie really wanted to let go of, especially given this loss?” King – who directed the original Sex and the City movie – noted how they wanted first-time viewers to relate to the moment as well, despite not knowing the original importance of the wedding dress. “It must mean something for someone who has never seen the scene where Carrie is left at the altar,” King told People. “So, you just have to create a story, like in that case, the Met Ball, which is named Veiled Beauty, which gets me to wedding veil, which gets to wedding gown, and then Carrie tells Smoke: ‘It wasn’t the best memory.’” “All you need to know is it was a bad moment that she’s putting it on, and then everybody gets to enjoy the gown.” And just like that, fans of the series took to Twitter on Thursday to applaud Carrie for repurposing the iconic wedding dress for the Met Gala. “CARRIE WEARING HER WEDDING DRESS AHH LOVE THE CHANGING THE NARRATIVE TO THAT DRESS,” one viewer tweeted. “I know it was supposed to be a sad moment but when Carrie threw on her wedding dress and veil and rocked it with them shoes and cape I was like yass!!!!” another person said. “Take that pain and sashay that gala”. A third fan wrote: “Carrie Bradshaw repurposed the Vivienne Westwood wedding dress and wore it to the MET Ball!! What a way to honour her,” which appears to refer to the designer’s death in December 2022. Although the return of the wedding dress was a nice surprise for fans of the original series, Parker and King detailed the lengths they had to go to retrieve the Vivienne Westwood gown. “We weren’t entirely certain that we could get the dress back,” Parker told People. “It was in London and unearthing it was complicated – getting it through customs in time and then making sure was this, in fact, the original dress? The colour looked different.” Not to mention Parker worried about fitting into the dress more than a decade later, adding that it “was terrifying to put it on”. “It was really incredible and fun and thank goodness it fit!” Parker said. “It was very special to have it back in our possession for a brief period and to figure out how it helped tell this story now.” The first two episodes of And Just Like That season two are available to stream on Max. Read The Indpendent’s two-star review here. Read More And Just Like That season two review: A toothless imitation of Sex and the City Sarah Jessica Parker’s son James explains why it feels ‘weird’ watching And Just Like That Sex and the City stars recall ‘near-death experience’ that occurred while filming season three Glastonbury 2023: All the best fashion at the biggest UK festival of the year Warehouse advert featured ‘unhealthily thin’ model, ASA rules Glastonbury festival fashion might not even exist anymore

WASHINGTON (Reuters) -U.S. Secretary of State Antony Blinken will travel to Tonga, New Zealand and Australia next week to discuss

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Welcome to Sun Blocked, Refinery29’s global call to action to wake up to the serious dangers of tanning. No lectures or shaming, we promise. Instead, our goal is to arm you with the facts you need to protect your skin to the best of your ability, because there’s no such thing as safe sun.

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