Paige Spiranac said, 'You know you're out there, poor Lucas Glover in these unbreathable pants, sweating like crazy'

New Zealand's prime minister on Wednesday joined a chorus of Kiwis complaining about the treatment of their national bird...

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Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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Seven races into the Formula 1 season and the moment has finally arrived. You can only bypass the trials and tribulations for so long before the tomfoolery of the sport’s most prestigious team must be dissected, head on. It’s time to talk about Ferrari. To say the 2023 campaign thus far has been underwhelming for the Scuderia would be in itself an understatement. Zero wins. Only one podium – in Baku – and even that was from a pole position start. Last time out in Barcelona, Charles Leclerc qualified a dismal 19th, failing to recover to a points-finish on Sunday. Carlos Sainz qualified second but could only manage fourth on raceday. Yet what makes Ferrari’s current infamy in motorsport’s most famous competition more baffling is their display in motorsport’s most famous endurance race. Because, returning to the 24 Hours of Le Mans last weekend for the first time in 50 years, Ferrari turned all predictions upside-down with a shock victory. Spearheaded by British driver James Calado, alongside former F1 star Antonio Giovvinazzi and Italian Alessandro Pier Guidi, Ferrari took their 10th Le Mans win and first in 58 years. It was a thrillingly impressive performance, beating favourites Toyota, in front of a sold-out 300,000 crowd at the centenary event. And what was it based on? Top-notch reliability, a clear-cut strategy throughout and straight-line speed which made the difference over the course of 342 laps. Can Ferrari’s F1 team take note? All the more, Leclerc was present in the garage in Le Mans, alongside F1 boss Fred Vasseur. How they must have both felt, seeing Ferrari’s best moment of 2023 so far play out in an endurance car as opposed to an F1 car. “It feels absolutely amazing, especially having a Ferrari winning,” Leclerc said afterwards. “I was here to support and I’m really happy that Ferrari won. It was an incredible experience.” Rewind a week and Leclerc was not so chirpy. “I don’t have the answer,” he exclaimed after his Q1 exit in Spain. What’s more, after the car returned to the factory in Maranello, a further sense of disconcertment. No obvious problem was identified. For a car which has thrived on Saturdays and struggled on Sundays, this was a discernible step backwards: a sense of direction which has been in motion for 12 months now. Ferrari’s last win in Formula 1 was in Austria, last July. 18 races have come and gone since then, with all but one won by Red Bull. This season, they trail Christian Horner’s team by 187 points already, languishing in fourth place. The point in time when Leclerc was a championship challenger seems a distant memory now. It’s hard to believe how far the Prancing Horse has fallen since his two wins from three to open up the 2022 season. The hope and realisation that the sport’s most famous team – who have not won a drivers’ title in 16 years, their longest-ever drought – were very much back in the top-end running was palpable. However, such potential has fallen off a cliff. No changing of the team principal, with Vasseur replacing the harshly axed Mattia Binotto in the off-season, has altered the stagnation. The Frenchman, too, is at a loss to explain the lack of consistency and progression. “We have 1,000 people [working] on this now and it is very difficult to understand and to fix it because it’s not always the same problem,” Vasseur said in Spain. When the boss is struggling to understand the issues at hand, there is a very tangible problem. Longer-term, you do wonder how long Leclerc’s patience in particular will last. The 25-year-old was linked with Mercedes last month, in a swap deal for Lewis Hamilton which seemed as fanciful then as it does now, with the Brit on the verge of signing a new deal. Leclerc’s anger in 2022 of the situation with his beloved team has now turned almost to an acceptance: an acceptance that ‘something has gone wrong… again… and we don’t how to fix it.’ And ahead of the Canadian Grand Prix this weekend, who knows what Ferrari will turn up in Montreal? The media don’t. The tifosi fans don’t. But most concerningly of all, the team don’t either. Read More Ferrari boss unhappy with ‘light’ Red Bull penalty for cost cap breach Ferrari chief orders ‘full investigation’ into Charles Leclerc’s retirement at Bahrain Grand Prix F1 2023 calendar: Every race this season Christian Horner reveals how close Fernando Alonso was to joining Red Bull Christian Horner reveals how close Fernando Alonso was to joining Red Bull

MCLEAN, Va.--(BUSINESS WIRE)--May 23, 2023--

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Don’t you wish you could be completely surrounded by your favorite fragrance? You already have the shampoo, perfume, and body oil, but you simply need more? Fans of the iconic Ouai scent Melrose Place are having their wildest dreams come true with the brand’s recent collaboration. DedCool, a personal and R29-favorite vegan fragrance brand, launched a limited-edition laundry Dedtergent in the Melrose Place scent.

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A former managing director opened up about a secret interview test that allowed him to understand whether the applicant was suitable for the job. In a resurfaced appearance on The Ventures podcast, Trent Innes, a former MD for Xero Australia Trent, said he would take the interviewee to a kitchen and offer them a drink. They would then take their drinks back to the meeting room where he would conduct the interview. He explained: "One of the things I’m always looking for at the end of the interview is, does the person doing the interview want to take that empty cup back to the kitchen?" The reason behind the subtle test comes down to attitude, according to Trent. "You can develop skills, you can gain knowledge and experience but it really does come down to attitude, and the attitude that we talk a lot about is the concept of 'wash your own coffee cup.'" Sign up for our free Indy100 weekly newsletter He believes there's more to the test than meets the eye, as it demonstrates that the candidate "would actually really drive a culture of ownership," for completing one of the "lowest level" tasks. "If you come into the office one day inside Xero, you’ll see the kitchens are almost always clean and sparkling and it’s very much off that concept of wash your coffee cup, but that sort of led into the interview space," he continued. Trent aimed to hire people who had "a real, strong ownership and a growth mindset." "It’s really just making sure they’re actually going to fit into the culture inside Xero, and really take on everything that they should be doing," he added. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Carol Vorderman was well and truly a sun worshipper growing up. “Oh God, yes. I was burning away merrily for many, many years,” she remembers with a groan. The former Countdown presenter, 62, says her generation was the first to really become obsessed with the sun. “I’m of the generation where we started to sunbathe – my mother’s generation didn’t. We were also caught in the formative years, the 60s, 70s, 80s, where we had absolutely no idea of what sun protection was – you just couldn’t buy it. I think it was the 90s that began,” she explains. “So in all of our youth we were encouraging each other to sunbathe doused in cooking oil.” Vorderman remembers the ways people would try and boost their tan – from sunbathing surrounded by metal foil (so you could “get all the rays of the sun” and “burn nicely”) to discovering sunbeds (“we thought they were marvellous”) – and she was particularly keen on soaking up as much of the sun as possible, as she grew up by the sea. She says anyone her age “will remember all that”, but now “we know the dangers”. Vorderman is unsurprised by Cancer Research UK’s latest statistics, showing melanoma skin cancer cases in the UK have reached an all-time high. According to the charity, 17,500 cases are diagnosed every year, with projections suggesting the numbers could increase by 50% over the next 20 years. Research suggests people around Vorderman’s age are increasingly affected, with the probability of people aged 55 and older getting skin cancer almost tripling since the 1990s. Bristol-based Vorderman herself had a scare when she was around 50. She was concerned by some changes in her skin, so went to see a dermatologist – who sent off a biopsy for testing, with results revealing the cells were precancerous. The presenter is at pains to emphasise she doesn’t want people to feel sorry for her – “I had no symptoms, nothing like that” and the cells were removed – but she’s instead trying to highlight how crucial it is to be sun safe. “What I do now is I’ve had a check-up every year, all over, ever since,” she says – and that isn’t the only change she’s made. “I slather myself in SPF at all opportunities. In many ways, the damage is already done, but I don’t sunbathe now, or I cover myself up.” Vorderman has teamed up with Boots brand Soltan and Macmillan Cancer Support on a sun-safety campaign, and her efforts to raise awareness around the issue aren’t just inspired by her own experiences. Her mother died in 2017 after suffering from three types of cancer – the third being melanoma. “Not a single time in her life did she sunbathe – my mum had a different skin to me, she had moles, I don’t,” Vorderman says. “I know that makes you much more prone to melanomas.” Cancer Research UK cites a study that found melanoma risk was higher in people with more than 100 moles compared with people who have fewer than 15 moles. For Vorderman, talking about these issues, whether publicly or among friends, is key. “It’s part of life. The more we talk about it, the better it is – as with everything. It’s like talking about the menopause, talking about women’s issues, talking about all sorts of cancers… As we know with all cancers, the sooner you can have something checked, the better the outcome should be.” Vorderman has in recent years made a name for herself for posting her unfiltered political beliefs on social media, and whether it’s talking about politics or causes close to her heart, she won’t back down. “I’ve always been pretty confident, but now you get to a point in life where you think – I feel strongly about things as they stand in this country at the moment. I’ve never known anything as bad. I think everyone should speak out.” She believes in the old saying: ‘The only thing necessary for evil to triumph is for good people to say nothing’, adding: “I take that with me.” Broadcaster and author Carol Vorderman MBE is working with Boots brand Soltan, which is joining forces with Macmillan Cancer Support for the second year running, as its official sun-safety partner.