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A recent investigation has found that some Ozempic and Wegovy patients suffered from severe gastroparesis, also known as stomach paralysis, after taking the medications. In a report from CNN published on 25 July, two patients reported that their “stomachs are paralysed” after taking type 2 diabetes drug Ozempic – a semaglutide injection known for its weight loss side effects. “I wish I never touched it. I wish I’d never heard of it in my life,” Joanie Knight, a 37-year-old from Louisiana, told CNN. “This medicine made my life hell. So much hell. It has cost me money. It cost me a lot of stress; it cost me days and nights and trips with my family. It’s cost me a lot, and it’s not worth it. The price is too high.” Emily Wright, a 38-year-old teacher from Toronto, said she vomits so frequently that she had to take a leave of absence from her job. “I’ve almost been off Ozempic for a year, but I’m still not back to my normal,” she said. According to CNN, both women have been diagnosed with severe gastroparesis, a disorder that slows or stops the movement of food from the stomach to the small intestine, per the Mayo Clinic. Wright has also been diagnosed with cyclic vomiting syndrome, which causes her to throw up multiple times a day. Meanwhile, one Wegovy user claimed she began experiencing stomach problems after her doctor prescribed her the weight loss drug – which works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), regulating blood sugar levels and slowing down the rate at which food leaves the stomach to create the feeling of fullness. However, the medication caused her to vomit so much that she became dehydrated and needed to visit urgent care. Brenda Allen, from Texas, has since been managing her nausea and vomiting with a medication called Zofran and prescription probiotics. Now, the US Food and Drug Administration has said they’ve received reports of stomach paralysis among patients taking the medications. “The FDA has received reports of gastroparesis with semaglutide and liraglutide, some of which documented the adverse event as not recovered after discontinuation of the respective product at the time of the report,” the agency said in a statement to CNN. However, officials clarified that they were unable to determine whether taking Ozempic or Wegovy was the cause of stomach paralysis, or if it was caused by a different issue. “Gastroparesis can be a complication of diabetes that is related to long-standing or poorly controlled disease, further complicating the ability to determine what role the drugs played in the reported events,” they said. As for whether patients should be warned about taking the drugs, the FDA maintained that taking the medications, such as for treating diabetes or weight management, may still “outweigh the risks in some patients with gastroparesis or delayed gastric emptying”. In response to reports of stomach paralysis, Novo Nordisk – the manufacturer behind Ozempic and Wegovy – noted that these drugs have been extensively studied in the real world and in clinical trials. “Gastrointestinal (GI) events are well-known side effects of the GLP-1 class,” the company told CNN. “For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration. GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects.” Last week, the American Society of Anesthesiologists also issued a warning that those who take GLP-1 agonists should avoid the medications a week before surgery because they may increase “risk of regurgitation and aspiration of food” while under anesthesia and deep sedation. Ozempic, a once-weekly injection used for the treatment of type 2 diabetes, has skyrocketed in use after people were reportedly prescribed the FDA-approved diabetes medication as an “off-label” weight loss drug. However, because of its increasing popularity, it has led to national shortages of the diabetes treatment - leaving those who actually need Ozempic without it. Meanwhile, Wegovy and Mounjaro are popular once-weekly semaglutide injections specifically approved for the treatment of obesity and weight loss. There are many side effects of taking medications like Ozempic, Wegovy, and Mounjaro. According to the FDA, the most common side effects of taking Wegovy are nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, and digestive disorders. The FDA has also warned about more serious complications that can occur from use of Wegovy or Mounjaro, such as the “potential risk of thyroid C-cell tumours,” pancreatitis, gallbladder problems, acute kidney injury, increased heart rate, and suicidal behaviour or thinking. Taking Ozempic can also lead to possible thyroid tumours, including cancer, pancreatitis, changes in vision, and kidney and gallbladder problems. The Independent has contacted Novo Nordisk and the FDA for comment. Read More Clinics told to stop prescribing medicines as weight loss drug hits diabetes supply Influencer addresses ‘dangers’ of complimenting people’s bodies after weight loss comments Ozempic under EU investigation over reports of suicidal thoughts Mindy Kaling shuts down weight loss question as ‘people take it so personally’ What are weight loss injections and what’s the controversy? Raven Symone says people shouldn’t use Ozempic for ‘glamazon purposes’

Daniel Ricciardo has been ruled out of this weekend’s Dutch Grand Prix after suffering a broken wrist in practice. The 34-year-old Australian, in only his third race back on the grid, crashed out of second practice in Zandvoort. He will be replaced in the AlphaTauri by Liam Lawson with the New Zealander to make his Formula One debut. Lando Norris denied Max Verstappen a practice double by setting the pace for Sunday’s grand prix – after Ricciardo crashed out and was taken to hospital. “After today’s incident during Free Practice 2 in Zandvoort, in which Daniel Ricciardo hit the barrier at Turn 3, he was brought to the local hospital and further examinations were carried out,” an AlphaTauri statement read. “An X-ray confirmed he sustained a break to a metacarpal on his left hand, and this injury will not allow him to continue his duties, so he will be replaced by the team’s reserve driver Liam Lawson for the remainder of this weekend. “The team wishes him all the best for the quickest possible recovery.” More than 300,000 spectators will descend on the coastal town of Zandvoort, 30 miles outside of Amsterdam, as Formula One emerges from its summer slumber. The majority of whom will do so in the expectation of watching Verstappen march to his ninth consecutive victory – equalling a record set by Sebastian Vettel for Red Bull in 2013 – as he closes in on a hat-trick of world championships. But McLaren’s Norris raised the suggestion he could spoil Verstappen’s homecoming party after he ended the day with the fastest time. While practice speed is treated with caution, the British driver edged out Verstappen, who was fastest in the first running, by just 0.023 seconds. The impressive Alex Albon finished third for Williams, one place ahead of Mercedes’ Lewis Hamilton. The seven-time world champion finished three tenths adrift in his Mercedes with team-mate George Russell only 14th in the order. “That was a great day for me,” said Hamilton. “I woke up this morning so excited to get back in the car and from the first lap it felt like we had a good starting point to work from. “The car is feeling more competitive here, so we want to hold on to that and see if we can extract more for tomorrow.” The second session was suspended after just 10 minutes when Norris’ team-mate Oscar Piastri and AlphaTauri’s Ricciardo crashed out at the same corner. Australian Piastri, who has enjoyed an impressive rookie campaign, lost control of his McLaren through the banked left-handed Turn 3 before slamming into the barriers. Moments later, Ricciardo, who appeared distracted by the sight of Piastri’s wounded McLaren, locked up under braking before following his compatriot into the tyre wall. “Ah f***, my hand, f***,” the 34-year-old said over the radio after the incident. Both men played no further part in the running as their damaged cars were towed back to their respective garages. Ricciardo was still holding the steering wheel as he hit the wall and he was taken to the medical centre. He was then pictured leaving with his left arm in a sling, and was subsequently taken to a nearby hospital for further checks on his wrist. The Australian will now sit out the remainder of the weekend. Red Bull motorsport adviser Dr Helmut Marko said after the crash: “We don’t know exactly what it is yet, but he was in a lot of pain. His wrist has suffered damage, but we have to wait for the diagnosis. “This is a new situation for us. We will first wait to see how Ricciardo is doing and whether he can drive or not, and then we discuss who gets in the car.” Ferrari have endured a lacklustre campaign and there was little for the Italian giants to cheer on Friday, with Charles Leclerc 11th and team-mate Carlos Sainz 16th. Ricciardo’s team-mate, Yuki Tsunoda, finished fifth with Pierre Gasly sixth and Sergio Perez, 125 points behind Verstappen in the drivers’ championship, seventh. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Haas announce Kevin Magnussen and Nico Hulkenberg staying for 2024 F1 Dutch Grand Prix LIVE: Daniel Ricciardo breaks metacarpal in left hand Daniel Ricciardo ruled out of Dutch Grand Prix

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