With new research emerging, more questions have been raised about weight-loss injections, how they work, and the risks involved. Here are some of your questions answered. What are weight loss injections? Championed by some celebrities, including Elon Musk, weight loss injections were originally created to treat people with type 2 diabetes and other weight-related health issues. They are a type of prescription-based medical treatment that interferes with your metabolism, regulates your appetite and as a result encourages weight loss. The drugs belong to a class of medications known as glucagon-like peptide-1 receptor agonists, or GLP-1 RAs, which mimic the GLP-1 hormone, released in the gut after eating some food. The only FDA-approved stomach injections to help with weight management are semaglutide — sold under the brand names Ozempic, Wegovy and Rybelsus — and liraglutide — sold under Saxenda. But others are in development. Helen Knight, programme director of the Centre for Health Technology Evaluation at the National Institute for Health and Care Excellence (Nice) said: “We know that management of overweight and obesity is one of the biggest challenges our health service is facing with nearly two-thirds of adults either overweight or obese. It is a lifelong condition that needs medical intervention, has psychological and physical effects, and can affect the quality of life. “But in recent years Nice has been able to recommend a new line of pharmaceutical treatments which have shown that those people using them, alongside changes to their diet and exercise, have been able to reduce their weight.” How do they work? According to Nice’s independent appraisal committee, drugs like semaglutide should only be prescribed to patients as an alternative for weight management — alongside a reduced-calorie diet and increased physical activity in adults. They should also have a BMI of at least 35.0 kg/m2 (this is medically classified as obese), and especially, to people with a BMI of 30.0 kg/m2 to 34.9 kg/m2, have non-diabetic hyperglycaemia (blood sugar that is above normal but below those needed to diagnose diabetes) or are at high risk of other weight-related conditions such as strokes and heart attacks, due to other factors such as high blood pressure and high cholesterol. Using semaglutide as an example, a typical dose for weight loss is 2.4 milligrams, administered weekly as under-the-skin self-injections. How are they going to be rolled out? Nice formally recommended liraglutide, orlistat and semaglutide as medicines suitable to use for weight loss earlier this year. And with such drugs also available through online pharmacies by private prescription, a growing number of people have tried the jabs. If they are prescribed alongside a reduced-calorie diet, increased physical activity, and behavioural support, after a year, people taking them can lose up to 15% of their body weight, with results visible within the first month, according to the Nice clinical trials. Some weight loss injections are available on the NHS, but they are only prescribed under certain circumstances. Following an announcement of a £40 million two-year pilot on June 7, the government have said more people living with obesity will have access to the newest and most effective obesity drugs to help cut NHS waiting lists. What are the possible side effects? Europe’s drug regulator The European Medicines Agency (EMA) is investigating whether patients using some weight loss and obesity jabs are at risk of suicidal thoughts and thoughts of self-harm, which highlights some of the controversy surrounding the phenomenon. The EMA safety committee said it is looking at cases among people who use a semaglutide or liraglutide-containing medicine for weight loss – where “signals” were raised by the Icelandic Medicines Agency. “A signal is information on a new or known adverse event that is potentially caused by a medicine and that warrants further investigation,” the EMA said. “The case reports included two cases of suicidal thoughts, one following the use of Saxenda and one after Ozempic. One additional case reported thoughts of self-injury with Saxenda. “The semaglutide-containing medicine Wegovy and the liraglutide-containing medicine Saxenda are authorised for weight loss, together with diet and physical activity. “Suicidal behaviour is not currently listed as a side-effect in the EU product information of these medicines.” If you have a history of medullary thyroid cancer, gallbladder disease, or even pancreatitis, you should avoid taking weight loss injections like semaglutide. People who do take the prescription drug for weight loss sometimes experience dizziness, fatigue, and gastrointestinal issues — the most common side effects among patients — such as diarrhoea, constipation and gassiness. They are also at risk of getting headaches and stomach conditions including vomiting, bloating and nausea. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Journalist and author Yomi Adegoke on the real-life consequences of social media What is group B strep? Charity says pregnant women ‘in the dark’ Britney Spears: I worked my ass off to get my memoir written

Young LGBT+ people who weren’t supported at home and school are more than twice as likely to have had suicidal thoughts and feelings than supported peers, a new report has found. Those from unsupportive backgrounds are also nearly twice as likely to have self-harmed, nearly half as likely to say they are happy in adulthood (43% vs 85%), and more than three times as likely to ‘never or rarely’ feel optimistic about their future – according to the findings from Just Like Us. The LGBT+ young people’s charity surveyed 3,695 people aged 18-25, including 1,736 LGBT+ young adults from across the UK. The ‘Positive Futures‘ report also found unsupported young LGBT+ people were significantly more likely to have experienced panic attacks and depression. What does an ‘unsupportive background’ mean? “An unsupportive time growing up can look like being bullied at school, never hearing that it’s OK to be LGBT+, facing family rejection and even estrangement, and not having any role models to look up to – all simply because you are LGBT+,” Amy Ashenden, Just Like Us interim CEO, told PA Media. “Sadly for lots of LGBT+ young people today, that remains a really gruelling reality. When we look at the research findings, we can see it’d be foolish to think growing up LGBT+ is not still incredibly tough.” How can you help support young LGBT+ people? Ashenden added: “Anyone who cares for and about young people has a role to play – whether or not you think they might come out as LGBT+ one day. We are calling particularly on parents, guardians and teachers to be more vocal in their support for LGBT+ people from the outset. “From the research, we know that LGBT+ young people wish they’d had these conversations from nursery age, which simply looks like saying: LGBT+ people exist and I support them. I’m proud to be an ally. “As a parent, you could mention a TV character or a person you know who is LGBT+ and you could mention how you admire their courage to be out and proud, or talk to them about how they are free to be who they are, different gender expressions included, and that you don’t agree with the harmful things sometimes said about trans people,” Ashenden said. Listening without judgement If a young person tells you they’re worried about coming out as LGBT+ and you’re unsure how to respond, remember there can be great value in just being a supportive listener. “The most important thing when a young person feels vulnerable or scared about coming out is providing a safe and supportive environment for that person to share their feelings, and to help them overcome their anxieties,” said Robert Common, an LGBT psychotherapist and founder/group CEO of The Beekeeper House. “Your role is to listen, and to allow them to express themselves without fear of judgement. You don’t need to be there to offer solutions – and be mindful of giving advice you’re not sure will be helpful or effective. You should remind them that they aren’t alone; there are many support groups and resources out there to help them.” Common added that ‘coming out’ isn’t just one conversation, either. For some young people, there may be anxiety about whether they will be accepted. “There’s a misconception that coming out is one big momentous point in time, but in reality, it’s a process. Although it shouldn’t be this way, the journey of acceptance can take a long time for some individuals, including family,” Common explained. “Young people in this situation should know that they should always come out on their own terms, whilst prioritising their safety and wellbeing. “If they do feel at risk from coming out to family, [gently encourage] them to talk through what the risks might look like and how to make contingency plans if they are faced with any kind of negative reaction or discrimination.” Signposting and community If a young LGBT+ person needs support and is facing difficulties, there are organisations that can help. Signposting them towards these can be a helpful step. For example, Common suggested: “The Albert Kennedy Trust (akt.org.uk), for LGBT young people who are homeless or living in a hostile environment. They can help with finding emergency accommodation as well as employment, education and training for those who need to support themselves.” Finding community can also be helpful – and “crucial for individuals that feel isolated or alone”, Common added. “The LGBTQ+ community is diverse, so when speaking to someone coming out, you can encourage them to see which parts of that community they identify with and relate to the most.” Many mental health charities like Mind (mind.org.uk) also offer specific advice for LGBTQ+ people, and the LGBT+ anti-abuse charity Galop (galop.org.uk) can provide support to those who have experienced violence or abuse. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live As Pride Month begins: 5 LGBTQ+ icons who have helped shape pop culture and history 10 ways to explain dementia to children How to make your home summer ready

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NEW YORK--(BUSINESS WIRE)--Sep 12, 2023--

Lewis Hamilton fears there is a “high chance” that Max Verstappen will win all 10 remaining races this season – and believes the Dutchman’s crushing dominance could last until 2026. Following a four-week summer shutdown, Formula One fires up this weekend at Verstappen’s home round in the Netherlands. Verstappen has won the last eight races and he will match Sebastian Vettel’s record of nine on the spin for Red Bull in 2013 if he triumphs in front of his orange-clad Dutch fans here on Sunday. Such is the dominance of Verstappen’s machine – and the two-time world champion’s supreme form – there is a feeling in the paddock, not only that Red Bull could become the first team to go through a campaign unbeaten, but that Verstappen could be victorious at each of the concluding 10 rounds. “There is a high chance that he (Verstappen) will win every race,” said Hamilton, 38. “He hasn’t made any mistakes and the team hasn’t made many this year. They might win everything. “But later on in the year, maybe we will get closer and we are hopeful we can challenge them at some point – whether that is this weekend, or who knows where? If there are any mistakes or mishaps, we will be right there to capitalise.” Verstappen has dominated since F1’s regulations were overhauled at the start of last season, with his comfortable victory at the concluding round before the break in Belgium his 10th from 12 so far and his 19th from his last 23 outings. He is a staggering 125 points clear in the standings as he closes in on a hat-trick of titles. Ferrari’s Charles Leclerc predicted on Thursday that it would be “very, very difficult” to catch Verstappen and Red Bull before the sport’s next major rule change in 2026. And Hamilton continued: “The fact is Red Bull are ahead and they have most likely started development on next year’s car a month before anybody else. It is very, very possible that Charles could be right. “We are working on the steep gradient to develop our car and close the gap. Whether or not we can, next year will be the proof.” I am hoping we are closer or in shooting range of a podium this weekend Lewis Hamilton Hamilton’s £40million-a-year contract expires at the end of the season and the Briton said on Thursday that were there was no update on his next deal, despite team principal Toto Wolff claiming – ahead of the Canadian Grand Prix on June 18 – that his star driver’s future would be resolved in “days rather than weeks”. Hamilton is fourth in the standings, 41 points adrift of Verstappen’s Red Bull team-mate Sergio Perez who occupies the runner-up spot, while Mercedes are second in the team standings, an eye-watering 256 points behind Red Bull, but 51 points clear of Ferrari. “It is a huge achievement to be second in the championship and it is something I feel has been overlooked,” said Hamilton. “We want to win but I am really proud of the team and the steps we have taken. “The guys think this track is not too different to Budapest and our car was good in Budapest. Even last year when the car was not great in Zandvoort, we were closer to the front. “George (Russell) finished second and at one point I was hunting down the lead so I am hoping we are closer or in shooting range of a podium this weekend. “We have the belief we will get there. And my goal is to try and keep that second place in the constructors’ championship and hunt down second in the drivers’ standings.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Haas announce Kevin Magnussen and Nico Hulkenberg staying for 2024 Lewis Hamilton gives blunt response to Felipe Massa’s legal action over 2008 title Charles Leclerc gives gloomy prediction on how quick Ferrari will catch Red Bull

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Max Verstappen is chasing another victory - what would be his 11th in a row - as Formula 1 returns to Asia for the popular Singapore Grand Prix at the Marina Bay Street Circuit. Verstappen broke the record for the most consecutive race wins last time out at Monza, overtaking Ferrari’s Carlos Sainz to win his 10th race in a row. The Dutchman is cruising to a third-straight F1 world championship and currently has a 145-point lead in the standings to team-mate Sergio Perez, though cannot clinch the title in Singapore. Zhou Guanyu interview: ‘There is a lot of pressure in F1 – only winners stay in this sport’ It was an improved performance from Ferrari in Italy, with Sainz securing his first podium of the year and Charles Leclerc finishing fourth, while the Mercedes duo of Lewis Hamilton and George Russell followed up their new contracts with sixth and fifth place respectively. Williams’ Alex Albon was a standout once again, finishing seventh. Perez won last year’s wet race under the lights in Singapore - a venue where Verstappen is yet to triumph in his career. Lewis Hamilton is a four-time winner in Marina Bay. Follow live updates from the Singapore Grand Prix with The Independent Read More FIA take action against Helmut Marko after comments about Sergio Perez Zhou Guanyu interview: ‘There is a lot of pressure in F1 – only winners stay in this sport’

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