The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’

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Lewis Hamilton insists locals living in Las Vegas “can’t be negatively affected” by Formula 1’s arrival in the city this week – and the sport should not turn into a “circus.” F1 holds its first grand prix in Vegas for more than 40 years this weekend, with a brand new street circuit which sees cars speed down the world-famous strip at over 200mph. But there has been a backlash among some locals due to the disruption caused by the construction of the track, including a $500m pit building facility. Tourists and taxi drivers have voiced their annoyance following traffic delays throughout the city as a result of road closures – and seven-time F1 world champion Hamilton believes the sport must stay “respectful” to locals. “I’ve heard there’s been a lot of complaints about the event being here from the locals,” Hamilton told Sky Sports News. “I think we have to be respectful of the locals here, so many people working so hard – there’s a lot of money and wealth in this city. “We’ve got to make sure people are taken care of. We can’t be a circus that shows up that’s all glitz and glamour and people are affected negatively by it, in my opinion.” Vegas will host the third F1 race of the season in the United States, following on from Miami in May and Austin last month. Hamilton admits it’s been “amazing” to see the growth of F1 ever since his debut in 2007 – and a stage when he had to “educate” Americans about the sport. “I’ve been here [in F1] now for 16 years – it’s been really impressive to see the growth of our sport,” Hamilton added. “I used to come to America, the first grand prix in 2007 in Indianapolis, and over the years always having to educate people about what this sport is about. “Knowing how big a sporting audience they have here and I just couldn’t understand why they weren’t drawn to sport like we were growing up, living with it “It’s been amazing to see the shift over the last couple of years, that the country is really embracing the sport and seem to love it just as much as we do.” Hamilton was speaking at a sponsors event on Tuesday night at Speed City on the outskirts of Las Vegas, with AMG collaborating with IWC for the launch of Mercedes’ new AMG GT Coupe’ road car. Read More Celebrities and sponsors descend on Las Vegas as F1 returns to Sin City How Formula 1 cracked America Bernie Ecclestone wouldn’t bet on F1’s future in Las Vegas ‘I would not be shocked if King Charles showed up’: Las Vegas opens its doors to F1 F1 2023 season race schedule: When is the Las Vegas Grand Prix? Michael Schumacher fans set for rare insight into F1 legend’s life in new documentary

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It’s no secret that Spice Girls star Geri Halliwell retired her famed flag dress and ditched her platform booties for preppy pieces and flat shoes, and now she has explained why. According to the 51-year-old, as her “Ginger Spice” era ended, so did her desire to don daring clothing like shimmery pencil skirts and ultra-cropped tops. Halliwell said that, as she’s gotten older, she’s started to feel a desire to streamline her wardrobe. During a conversation with Jenna Bush Hager for the 4 October episode of Today With Hoda & Jenna, Halliwell said: “I don’t know about you, but as you get older, you want to keep it simple. And one thing I’ll say is everything matches. It’s just fast, fast.” From halters to high-neck solid shirts, the “Wannabe” singer explained her style change to be inspired by men surprisingly. “You look at the men who are always wearing these same things, a uniform,” Halliwell remarked. “Can’t I do the same? Why not?” Now, the music icon – known for her eccentric on-stage energy and fiery red hair with bleached streaks – has assumed a neutral palette, sticking to mostly monochromatic looks. When asked about her iconic Union Jack mini, Halliwell admitted the design was motivated by a common kitchen essential. “I made that dress out of a tea towel,” she confessed. While the vibrant performer may not wear jewelled one-pieces, she’s adopted versions of her former favourite. Most recently, Halliwell lengthened the Union Jack gown, before reimagining the entire design to be a ball gown with a straight neckline. Speaking to Vogue in 2020, the author opened up about how altering her old emblem only made the garment more special. “I felt a sense of power in developing the dress into something different, something even more timeless,” she noted. “For me, it shows the revolution of being a woman.” “The way I dress has always reflected how I feel about myself at that time,” she continued. Halliwell tied the knot with Christian Horner in May of 2015. The two were first aquainted during her Ginger Spice days when the group of girls were invited to the 2009 Monaco Grand Prix with Bernie Ecclestone. However, Halliwell and Horner ignited their whirlwind romance in 2014, developing their connection for one year before saying “I do.” Before getting hitched, Halliwell welcomed her daughter Bluebell, 11, with her previous partner. In 2017, she gave birth to her second child, Montague. Read More Spice Girls star Geri Horner says having children is a ‘better’ achievement than a No 1 record Geri Halliwell says her ‘sillier self came out’ when she met husband Christian Horner Geri Halliwell recalls learning her father died while studying Hamlet: ‘It woke me up to my own mortality’ Kim Kardashian criticised for modelling in Balenciaga after brand’s campaign scandal 4 must-have denim trends for autumn, from wide-leg jeans to split skirts Zendaya recreates Naomi Campbell’s iconic Louis Vuitton 2004 ad in an elevator

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