Asahi Group Holdings Ltd. has become the first Japanese brewer to become an official sponsor of the Rugby

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TL;DR: A lifetime subscription to the Noiselab Music Production Hub is on sale for £49.25,

Alfa Romeo have announced that both Valtteri Bottas and Zhou Guanyu will remain with the team for the 2024 F1 season. The pair, who have worked together at Alfa since the start of the 2022 campaign, will team up for a third consecutive season, Alfa confirmed on Thursday. Bottas has a deal with the team until 2025 - signed upon his arrival from Mercedes at the end of 2021 - while Zhou has signed a one-year extension. Alfa also confirmed that Theo Pourchaire, who is on the cusp of winning this year’s Formula 2 title, will be their reserve driver once again. 2024 will be Bottas’ 12th straight season in Formula 1 while Zhou, the first Chinese driver in the sport, will race at his home grand prix for the first time when the Chinese Grand Prix returns to the calendar in April. “Signing again with the team is always a great feeling, especially when we know how things are shaping up,” Zhou said. “I am proud to be part of Alfa Romeo F1 Team Stake and grateful for their trust: I have been working extremely hard since day one and there is an incredible level of motivation to keep doing so every day forward. “My relationship with Valtteri is really good, and we are working closely together and with the team to push everyone forward. I am also very excited about the opportunity to finally race with my team in China, in front of my home crowd. “It will be a great moment and I’m proud to be able to share it with all those who have supported me.” The Sauber-works team are being taken over by German giant Audi for the 2026 season when new regulations come into force. Bottass added: “I have a feeling we have an exciting journey ahead of us, so I am happy and grateful to be able to look forward to 2024 knowing how the team is shaping up. “There is a good atmosphere within our squad, I get along with Zhou and we both push each other hard to improve. There is an impressive amount of work going on behind the scenes, in Hinwil and beyond, and now that the line-up is set for next year, we can focus fully on improving, starting this weekend in Singapore already. “Every step forward we make is a step forward for this year and next, so we are motivated to give everything we have every time we’re trackside or at the factory.” Alfa have struggled for car performance so far this season and have only amassed 10 points after the first 14 races of the season. Bottas has six points, while Zhou has four. They currently lie ninth in the Constructors’ Standings, with only AlphaTauri below them. Read More F1 2023 season race schedule: When is the Singapore Grand Prix? Lando Norris could leave McLaren at end of the season, claims Nico Rosberg Toto Wolff slams ‘moaning’ across F1 grid after Lewis Hamilton apology F1 Singapore Grand Prix: When is practice on Friday at Marina Bay? Red Bull chief apologises to Sergio Perez over ‘offensive remark’ Sky F1 star escapes after car bursts into flames at Goodwood

American Airlines Group Inc. joined a growing number of carriers around the globe that have discovered improperly certified

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Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

ANOKA, Minn.--(BUSINESS WIRE)--Jul 21, 2023--

Taylor Hill shared the drastic change she witnessed in her beloved pet Tate going from 'fine one day' to 'the sickest I've ever seen him'

CARLSBAD, Calif.--(BUSINESS WIRE)--Jul 17, 2023--