List of All Articles with Tag 'p'

Carmelo Anthony, one of the greatest scorers the NBA has ever seen, has announced his retirement from basketball at the age of 38.

An electric guitar smashed up and signed by the late Nirvana front man Kurt Cobain has sold for almost 10 times its estimated value.

Canadian duck and goose farmers call the controversial delicacy the most "maligned and misunderstood food in the world."

Republican Nebraska Gov. Jim Pillen is scheduled to sign a bill Monday that bans abortion at 12 weeks of pregnancy and restricts gender-affirming medical care for people younger than 19

A former soldier who lost both his legs in an explosion in Afghanistan has made history by conquering Everest.

If you’re not sure whether you want to spend your summer exploring the coast of California or making your way through the Mediterranean, the new Mango x Simon Miller collaboration is here to provide the warm-weather wardrobe of your dreams no matter where your vacation takes you.

Nettles, dandelions, brambles: weeds -- once considered a scourge -- are taking pride of place at London's Chelsea Flower Show as gardeners concern themselves more than...

LOUISVILLE, Ky.--(BUSINESS WIRE)--May 22, 2023--

Natalie Portman donned an exclusive Dior design to attend the premiere of her upcoming film 'May December' at the Cannes Film Festival

OKLAHOMA CITY--(BUSINESS WIRE)--May 22, 2023--

Ryanair Holdings Plc dangled the prospect of paying a dividend should the Irish low-cost airline extend its strong

The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’